7-甲氧基香豆素-3-羰基叠氮化物 | 97632-67-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 7-甲氧基香豆素-3-羰基叠氮化物
• 英文名称: 7-methoxycoumarin-3-carbonyl azide
• 英文别名: 7-methoxy-2-oxochromene-3-carbonyl azide
• CAS: 97632-67-2
• 化学式: C₁₁H₇N₃O₄
• 分子量: 245.194
• InChiKey: KIPIRQVNIGOHCO-UHFFFAOYSA-N

物化性质

• 溶解度：
  Soluble in acetonitrile, chloroform, N,Ndimethylformamide, methanol
• 最大波长(λmax)：
  360 nm (MeOH)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  67
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2932209090

反应信息

• 作为反应物：
  描述：

  胆固醇 、 7-甲氧基香豆素-3-羰基叠氮化物 以 四氢呋喃 为溶剂， 反应 1.0h， 以77%的产率得到(7-Methoxy-2-oxo-2H-chromen-3-yl)-carbamic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester
  参考文献：
  名称：

  Takadate, Akira; Irikura, Mitsuru; Suehiro, Tsutomu, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 3, p. 1164 - 1169

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氯甲酰基-7-甲氧基香豆素 在 sodium azide 作用下， 以 丙酮 为溶剂， 反应 2.0h， 生成 7-甲氧基香豆素-3-羰基叠氮化物
  参考文献：
  名称：

  Takadate, Akira; Irikura, Mitsuru; Suehiro, Tsutomu, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 3, p. 1164 - 1169

  摘要：

  DOI：

文献信息

• INDICATOR FOR ASSESSING BODY ODOR, PROCESS FOR PRODUCING THE SAME, BODY ODOR ASSESSMENT METHOD, METHOD OF ASSESSING EFFICACIOUSNESS OF DEODORANT AND KIT FOR CONVENIENTLY ASSESING BODY ODOR
  申请人：Kao Corporation

  公开号：EP1553411A1

  公开（公告）日：2005-07-13

  An indicator material for assessing body odor of the present invention comprises at least one member selected from the group consisting of a substance (A) which is a β-hydroxycarboxylic acid compound represented by the formula (1), a substance (B) which is a derivative of the compound represented by the formula (1), a substance (C) which is an alcohol compound having a mercapto group at the 3-position represented by the formula (2),and a substance (D) which is a derivative of the compound represented by the formula (2). The present invention also provides a method of producing the compound represented by the formula (2) by incubating perspiration originated from a human in an environment with an oxygen concentration of 10 v/v% or less. The present invention also provides a kit for assessing body odor of a human, wherein the kit for assessing body odor of a human includes a coloration reagent which reacts with β-hydroxycarboxylic acid originated from perspiration of a human. wherein R1 is an alkyl having 1 to 4 carbons; R2 is a hydrogen atom or an alkyl having 1 to 4 carbons, and the total number of carbons in the formula (1) is 10 or less; wherein R3 is a hydrogen atom or methyl group; R4 is an alkyl group having 1 to 3 carbons; and R5 is a hydrogen atom or a methyl group, the total number of carbons is 8 or less.

  本发明的一种用于评估体味的指示剂材料包括至少一种选自以下组成的成员：一种物质（A），它是β-羟基羧酸化合物，由式（1）表示；一种物质（B），它是由式（1）表示的化合物的衍生物；一种物质（C），它是由式（2）表示的在3-位上具有巯基的醇化合物；以及一种物质（D），它是由式（2）表示的化合物的衍生物。本发明还提供了一种通过在氧气浓度为 10 v/v% 或更低的环境中培养人的汗液来生产式（2）所代表的化合物的方法。本发明还提供了一种用于评估人的体味的试剂盒，其中用于评估人的体味的试剂盒包括一种与源自人的汗液的β-羟基羧酸反应的着色试剂。 其中 R1 是具有 1 至 4 个碳原子的烷基；R2 是氢原子或具有 1 至 4 个碳原子的烷基，且式（1）中的碳原子总数为 10 或更少； 其中 R3 是氢原子或甲基；R4 是具有 1 至 3 个碳原子的烷基；R5 是氢原子或甲基，碳原子总数为 8 或更少。
• Active self-healing biomaterial system
  申请人：The Regents of the University of Michigan

  公开号：US10220001B2

  公开（公告）日：2019-03-05

  Methods and compositions are provided that load and encapsulate an agent, such as a protein, in a porous self-healing polymer. A delivery system includes a porous self-healing polymer, an ionic affinity trap within the pores of the self-healing polymer, and an agent associated with the ionic affinity trap. Methods of encapsulating an agent in a polymer include providing a porous self-healing polymer comprising an ionic affinity trap within the pores. The polymer is incubated with an agent having an affinity for the ionic affinity trap. At least a portion of the pores in the polymer are then healed. Active encapsulation of macromolecules at low concentrations may be achieved due to affinity of the agent for the ionic affinity trap within the pores.

  本发明提供了在多孔自愈合聚合物中装载和封装药剂（如蛋白质）的方法和组合物。递送系统包括多孔自愈合聚合物、自愈合聚合物孔隙中的离子亲和阱以及与离子亲和阱相关的药剂。将药剂封装在聚合物中的方法包括提供一种多孔自愈合聚合物，其孔隙内包含离子亲和阱。聚合物与对离子亲和阱具有亲和力的药剂一起培养。聚合物中至少有一部分孔隙会随之愈合。由于孔隙内的离子亲和捕集剂对药剂具有亲和力，因此可以在低浓度下实现大分子的活性封装。
• Lactam polymer derivatives
  申请人：Arnold C. Stephen

  公开号：US20060069235A1

  公开（公告）日：2006-03-30

  Lactam polymers has been modified with sodium borohydride (NaBH 4 ) to yield lactam polymers bearing hydroxyl functional groups. These functional groups are useful for the covalent attachment of reactive groups, fluorescent probes, antimicrobial agents, bioactive factors, and drugs. The resulting as components for medical devices, specifically ophthalmic devices and more specifically contact lenses. Hydrogels based on these polymers are also useful for biomedical applications in the areas of drug delivery, tissue engineering, and implantable devices.

  内酰胺聚合物用硼氢化钠（NaBH 4 ) 对内酰胺聚合物进行改性，从而得到带有羟基官能团的内酰胺聚合物。这些官能团可用于共价连接活性基团、荧光探针、抗菌剂、生物活性因子和药物。这些聚合物可用作医疗设备的组件，特别是眼科设备，尤其是隐形眼镜。基于这些聚合物的水凝胶还可用于药物输送、组织工程和植入设备等领域的生物医学应用。
• Indicator for assessing body odor, process for producing the same, body odor assessment method, method of assessing efficaciousness of deodorant and kit for conveniently assessing body odor
  申请人：Hasegawa Yoshihiro

  公开号：US20060160240A1

  公开（公告）日：2006-07-20

  An indicator material for assessing body odor of the present invention comprises at least one member selected from the group consisting of a substance (A) which is a β-hydroxycarboxylic acid compound represented by the formula (1), a substance (B) which is a derivative of the compound represented by the formula (1), a substance (C) which is an alcohol compound having a mercapto group at the 3-position represented by the formula (2),and a substance (D) which is a derivative of the compound represented by the formula (2). The present invention also provides a method of producing the compound represented by the formula (2) by incubating perspiration originated from a human in an environment with an oxygen concentration of 10 v/v % or less. The present invention also provides a kit for assessing body odor of a human, wherein the kit for assessing body odor of a human includes a coloration reagent which reacts with β-hydroxycarboxylic acid originated from perspiration of a human.

  本发明的一种用于评估体味的指示剂材料包括至少一种选自以下组成的成员：一种物质（A），它是β-羟基羧酸化合物，由式（1）表示；一种物质（B），它是由式（1）表示的化合物的衍生物；一种物质（C），它是由式（2）表示的在3-位上具有巯基的醇化合物；以及一种物质（D），它是由式（2）表示的化合物的衍生物。本发明还提供了一种通过在氧气浓度为 10 v/v % 或更低的环境中培养人的汗液来生产式（2）所代表的化合物的方法。本发明还提供了一种用于评估人的体味的试剂盒，其中用于评估人的体味的试剂盒包括一种着色试剂，该试剂与源自人的汗液的β-羟基羧酸反应。
• EP1585971A4
  申请人：——

  公开号：EP1585971A4

  公开（公告）日：2006-06-07