4'-methylbiphenyl-2-carbohydrazide | 144625-45-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-methylbiphenyl-2-carbohydrazide
• 英文别名: 2-(4-methylphenyl)benzohydrazide
• CAS: 144625-45-6
• 化学式: C₁₄H₁₄N₂O
• 分子量: 226.278
• InChiKey: LGBAGYWRPIVICE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4'-methylbiphenyl-2-carbohydrazide 在 2,4,6-三甲基吡啶 、 N-羟基邻苯二甲酰亚胺 、 lithium perchlorate 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以58%的产率得到2-甲基-9H-芴-9-酮
  参考文献：
  名称：

  N-Hydroxyphthalimide-Mediated Electrochemical Denitrogenation of Aroylhydrazides to Generate Acyl Radicals and Their Applications in the Syntheses of Fluorenones

  摘要：

  DOI：

  10.1021/acs.joc.1c01262
• 作为产物：
  描述：

  3-甲基-[1,1-联苯]-2-羧酸 、 草酰氯 、 一水合肼 在 N,N-二甲基甲酰胺 乙酸乙酯 、 水 、 silica gel 、 Chloroform;2-propan-2-yloxypropane 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 22.0h， 以afforded the title compound as colorless needles (4.3 g, 63%), m.p.98°-99° C.的产率得到4'-methylbiphenyl-2-carbohydrazide
  参考文献：
  名称：

  Compound which is angiotensin II antagonist

  摘要：

  以上公式所示的化合物或其盐具有强烈的血管紧张素II拮抗活性、降压作用和中枢神经系统活性，可用作循环系统疾病（如高血压病和心脏病（例如心肌肥大、心力衰竭、心肌梗死）、中风、脑卒中、肾炎、动脉硬化、阿尔茨海默病、老年性痴呆等）的治疗剂。

  公开号：

  US05243054A1

文献信息

• Salicylic acid derivatives, processes for their preparation, compositions comprising them, their use
  申请人：——

  公开号：US20020032178A1

  公开（公告）日：2002-03-14

  Salicylic acid derivatives of the formula I, 1 where the index and the substituents have the following meanings: X is halogen, NO 2 , cyano, alkyl or alkoxy; m is 0, 1, 2 or 3, it being possible for the substituents X to be different from each other if n is greater than 1; A is OH, alkoxy, NH 2 , NHCH 3 or N(CH 3 ) 2 ; R 1 is phenyl, naphthyl, cycloalkyl, 5-membered or 6-membered hetaryl or 5-membered or 6-membered heterocyclyl, comprising one to three N atoms and/or one O or S atom or one or two O and/or S atoms, the ring systems being unsubstituted or substituted; R 2 is hydrogen, cyano, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy or alkylthio, processes for the preparation of these compounds, compositions comprising them, and their use for controlling harmful fungi.

  公式I中的水杨酸衍生物，其中指数和取代基具有以下含义：X是卤素，NO2，氰基，烷基或烷氧基；m为0、1、2或3，如果n大于1，则取代基X可以不同；A是OH，烷氧基，NH2，NHCH3或N（CH3）2；R1是苯基，萘基，环烷基，5元或6元杂芳基或5元或6元杂环烷基，包括一个到三个N原子和/或一个O或S原子或一个或两个O和/或S原子，环系统未取代或取代；R2是氢，氰基，烷基，烯基，炔基，卤代烷基，烷氧基或烷基硫代基，制备这些化合物的方法，包含它们的组合物以及它们用于控制有害真菌的用途。
• Dinitrogen heterocyclic derivatives N-substituted by a biphenylmethyl
  申请人：Elf Sanofi

  公开号：US05268375A1

  公开（公告）日：1993-12-07

  This invention relates to compounds of formula ##STR1## in which: R.sub.1 and R.sub.2 are similar or different and are each independently hydrogen or a group selected from CO.sub.2 N.dbd.C(NH.sub.2).sub.2, CONHNHCONH.sub.2, CONHNHCSNH.sub.2, C(OC.sub.2 H.sub.5).dbd.NCO.sub.2 CH.sub.3, COCH.sub.2 CO.sub.2 H.sub.5, N(OH)-CONHCOOC.sub.2 NCO.sub.2 CH.sub.3, COCH.sub.2 CO.sub.2 H.sub.5, N(OH)-CONHCOOC.sub.2 H.sub.5, C(OC.sub.2 H.sub.5).dbd.NH or a nitrogen heterocycle; with the proviso that at least one of the substituents R.sub.1 or R.sub.2 is other than hydrogen; R.sub.3 is a hydrogen, a C.sub.1 -C.sub.6 alkyl, a C.sub.2 -C.sub.6 alkenyl, a C.sub.3 -C.sub.7 cycloalkyl, a phenyl, a phenylalkyl, or a phenylalkenyl; R.sub.4 and R.sub.5 are each independently a C.sub.1 -C.sub.6 alkyl, a C.sub.3 -C.sub.7 cycloalkyl, a phenyl or a phenylalkyl; or R.sub.4 and R.sub.5, bonded together, are either a group of the formula (CH.sub.2).sub.n or a group of the formula (CH.sub.2).sub.p Y (CH.sub.2).sub.q, in which Y is either an oxygen atom, or a sulfur atom, or a substituted carbon atom, or a group N-R.sub.6, in which R.sub.6 is a hydrogen, a C.sub.1 -C.sub.4 alkyl, a phenylalkyl, a C.sub.1 -C.sub.4 alkylcarbonyl, a C.sub.1 -C.sub.4 halogenoalkylcarbonyl, a C.sub.1 -C.sub.4 polyhalogenoalkylcarbonyl, a benzolyl, an .alpha.-aminoacyl or a N-protecting group, or R.sub.4 and R.sub.5, together with the carbon atom to which they are bonded, form an indane or an adamantine; p+q=m; n is an integer between 2 and 11; m is an integer between 2 and 5; X is an oxygen or a sulfur atom; and z and t are zero or z+t=1; and its salts.

  本发明涉及公式##STR1##的化合物，其中：R.sub.1和R.sub.2相似或不同，且各自独立地为氢或从CO.sub.2 N.dbd.C(NH.sub.2).sub.2、CONHNHCONH.sub.2、CONHNHCSNH.sub.2、C(OC.sub.2 H.sub.5).dbd.NCO.sub.2 CH.sub.3、COCH.sub.2 CO.sub.2 H.sub.5、N(OH)-CONHCOOC.sub.2 NCO.sub.2 CH.sub.3、COCH.sub.2 CO.sub.2 H.sub.5、N(OH)-CONHCOOC.sub.2 H.sub.5、C(OC.sub.2 H.sub.5).dbd.NH或氮杂环中选择的基团；但须满足R.sub.1或R.sub.2中至少有一个基团不是氢；R.sub.3为氢、C.sub.1-C.sub.6烷基、C.sub.2-C.sub.6烯基、C.sub.3-C.sub.7环烷基、苯基、苯基烷基或苯基烯基；R.sub.4和R.sub.5各自独立地为C.sub.1-C.sub.6烷基、C.sub.3-C.sub.7环烷基、苯基或苯基烷基；或R.sub.4和R.sub.5结合在一起，形成公式(CH.sub.2).sub.n或公式(CH.sub.2).sub.p Y (CH.sub.2).sub.q的基团，其中Y为氧原子、硫原子、取代碳原子或基团N-R.sub.6，其中R.sub.6为氢、C.sub.1-C.sub.4烷基、苯基烷基、C.sub.1-C.sub.4烷基羰基、C.sub.1-C.sub.4卤代烷基羰基、C.sub.1-C.sub.4多卤代烷基羰基、苯并环、α-氨基酰基或N-保护基；或R.sub.4和R.sub.5与它们结合的碳原子一起形成茚环或金刚烷；p+q=m；n为2到11之间的整数；m为2到5之间的整数；X为氧原子或硫原子；z和t为零或z+t=1；以及其盐。
• Compound and salts thereof which antagonize angiotensin II
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05354766A1

  公开（公告）日：1994-10-11

  ##STR1## Compounds shown by the above formula or salt thereof show a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases and heart diseases (e.g. hypercardia, heart failure, cardiac infarction), strokes, cerebral apoplexy, nephritis, atherosclerosis, Alzheimer's disease, senile dementia, etc.

  上述公式所示的化合物或其盐表现出强烈的血管紧张素II拮抗活性、降压作用和中枢神经系统活性，可用作治疗循环系统疾病，如高血压病和心脏疾病（例如心肌病、心力衰竭、心肌梗塞）、中风、脑卒中、肾炎、动脉硬化、阿尔茨海默病、老年痴呆症等的治疗剂。
• Heterocyclic compounds and their use as angiotensin antagonists
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05736555A1

  公开（公告）日：1998-04-07

  ##STR1## Compounds shown by the above formula or salt thereof show a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases and heart diseases (e.g. hypercardia, heart failure, cardiac infarction), strokes, cerebral apoplexy, nephritis, atherosclerosis, Alzheimer's disease, senile dementia, etc.

  上述公式所示的化合物或其盐具有强烈的血管紧张素II拮抗活性、降压作用和中枢神经系统活性，并可用作循环系统疾病（如高血压病和心脏病，如心脏肥大、心力衰竭、心肌梗死）、中风、脑卒中、肾炎、动脉硬化、阿尔茨海默病、老年痴呆症等治疗剂。
• Salicylic acid derivatives, processes for their preparation, compositions comprising them, and their use
  申请人：BASF Aktiengesellschaft

  公开号：US06593315B2

  公开（公告）日：2003-07-15

  Salicylic acid derivatives of the formula I, where the index and the substituents have the following meanings: X is halogen, NO2, cyano, alkyl or alkoxy; m is 0, 1, 2 or 3, it being possible for the substituents X to be different from each other if n is greater than 1; A is OH, alkoxy, NH2, NHCH3 or N(CH3)2; R1 is phenyl, naphthyl, cycloalkyl, 5-membered or 6-membered hetaryl or 5-membered or 6-membered heterocyclyl, comprising one to three N atoms and/or one O or S atom or one or two O and/or S atoms, the ring systems being unsubstituted or substituted; R2 is hydrogen, cyano, alkyl, alkenyl, alkynyl, haloalkyl, alkoxy or alkylthio, processes for the preparation of these compounds, compositions comprising them, and their use for controlling harmful fungi.

  公式I中的水杨酸衍生物，其中指数和取代基具有以下含义：X是卤素，NO2，氰基，烷基或烷氧基；m为0，1，2或3，如果n大于1，则取代基X可以彼此不同；A为OH，烷氧基，NH2，NHCH3或N（CH3）2；R1为苯基，萘基，环烷基，五元或六元杂芳基或含有一个至三个N原子和/或一个O或S原子或一个或两个O和/或S原子的五元或六元杂环基，环系统未取代或取代；R2为氢，氰基，烷基，烯基，炔基，卤代烷基，烷氧基或烷硫基，制备这些化合物的方法，包括它们的组成物，以及它们用于控制有害真菌的用途。