4--3-phenylcinnolin | 10604-52-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4--3-phenylcinnolin
• 英文别名: N,N,N'-trimethyl-N'-(3-phenyl-cinnolin-4-yl)-ethane-1,2-diamine；N~1~,N~1~,N~2~-Trimethyl-N~2~-(3-phenylcinnolin-4-yl)ethane-1,2-diamine；N,N,N'-trimethyl-N'-(3-phenylcinnolin-4-yl)ethane-1,2-diamine
• CAS: 10604-52-1
• 化学式: C₁₉H₂₂N₄
• 分子量: 306.41
• InChiKey: LJQMHFNVEQKNMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Lithium N-(N,N-dimethyl-2-aminoethyl)-N-methylamide 、 1-苯基-2-(2,2,2-三氟-1-苯基亚乙基)肼 以 四氢呋喃 为溶剂， 以52%的产率得到4--3-phenylcinnolin
  参考文献：
  名称：

  Trifluoromethyl group in the synthesis of heterocyclic compounds: New and efficient synthesis of 3-aryl-4-aminocinnolines

  摘要：

  A novel base induced transformation of hydrazones 3a-f derived from trifluoromethylaryl ketones and arylhydrazines was found to produce 3-aryl-4-aminocinnolines 4a-g in 52-75% yield. The initial step of the reaction is believed to involve abstraction of Hf from hydrazone.

  DOI：

  10.1016/0040-4039(95)00005-w

文献信息

• Trifluoromethyl group in the synthesis of heterocyclic compounds: New and efficient synthesis of 3-aryl-4-aminocinnolines
  作者：Alexander S. Kiselyov

  DOI：10.1016/0040-4039(95)00005-w

  日期：1995.2

  A novel base induced transformation of hydrazones 3a-f derived from trifluoromethylaryl ketones and arylhydrazines was found to produce 3-aryl-4-aminocinnolines 4a-g in 52-75% yield. The initial step of the reaction is believed to involve abstraction of Hf from hydrazone.