N-(Diphenylmethylene)-α-(2,2'-dipyridyl-6-methyl)glycine methyl ester | 145250-67-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(Diphenylmethylene)-α-(2,2'-dipyridyl-6-methyl)glycine methyl ester
• 英文别名: Methyl 2-(benzhydrylideneamino)-3-(6-pyridin-2-ylpyridin-2-yl)propanoate
• CAS: 145250-67-5
• 化学式: C₂₇H₂₃N₃O₂
• 分子量: 421.499
• InChiKey: RQHQBVIDMZYPSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  64.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(Diphenylmethylene)-α-(2,2'-dipyridyl-6-methyl)glycine methyl ester 在 盐酸 、 TEA 、 氢气 、 肼 、 sodium nitrite 作用下， 以 乙醚 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 29.25h， 生成 (R)-2-(2-Acetylamino-3-[2,2']bipyridinyl-6-yl-propionylamino)-3-benzoylsulfanyl-propionic acid methyl ester
  参考文献：
  名称：

  Bipyridyl amino acid-metal complexes and their characterization by electrospray mass spectrometry

  摘要：

  The syntheses of bipyridylalanine and related bipyridyl-functionalized peptide derivatives are described. The copper complexes of several peptide-bipyridyls were prepared and characterized. Application of electrospray ionization mass spectrometry to the structure determination of cationic bipyridyl Cu+ complexes 2 and 3, as well as peptide-metal complexes 18-22, was explored.

  DOI：

  10.1021/jo00051a049
• 作为产物：
  描述：

  二苯亚甲基甘氨酸甲酯 、 6-(溴甲基)-2,2'-联吡啶 在 sodium hydroxide 、 四丁基硫酸氢铵 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以81%的产率得到N-(Diphenylmethylene)-α-(2,2'-dipyridyl-6-methyl)glycine methyl ester
  参考文献：
  名称：

  Bipyridyl amino acid-metal complexes and their characterization by electrospray mass spectrometry

  摘要：

  The syntheses of bipyridylalanine and related bipyridyl-functionalized peptide derivatives are described. The copper complexes of several peptide-bipyridyls were prepared and characterized. Application of electrospray ionization mass spectrometry to the structure determination of cationic bipyridyl Cu+ complexes 2 and 3, as well as peptide-metal complexes 18-22, was explored.

  DOI：

  10.1021/jo00051a049

文献信息

• Bipyridyl amino acid-metal complexes and their characterization by electrospray mass spectrometry
  作者：Stephen R. Wilson、Arfa Yasmin、Yunhui Wu

  DOI：10.1021/jo00051a049

  日期：1992.12

  The syntheses of bipyridylalanine and related bipyridyl-functionalized peptide derivatives are described. The copper complexes of several peptide-bipyridyls were prepared and characterized. Application of electrospray ionization mass spectrometry to the structure determination of cationic bipyridyl Cu+ complexes 2 and 3, as well as peptide-metal complexes 18-22, was explored.