2-amino-3-phenyl-propanol-1-acetate | 145059-73-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-3-phenyl-propanol-1-acetate
• 英文别名: (2-Amino-3-phenylpropyl) acetate
• CAS: 145059-73-0
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: BNFPQZUZYHKBQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-3-phenyl-propanol-1-acetate 在 二氢吡啶 作用下， 以 乙醇 、 水 、 二甲基亚砜 为溶剂， 反应 24.0h， 生成 methyl 5-acetoxy-4-benzyl-2-(di-(tert-butoxycarbonyl)amino)pentanoate
  参考文献：
  名称：

  用于合成非天然 α-氨基酸的脱氢丙氨酸的生物相容性光诱导烷基化

  摘要：

  描述了脱氢丙氨酸的位点选择性烷基化以获取受保护的非天然氨基酸。该协议的特点是所用烷基的广泛性质、温和的条件和官能团兼容性。该协议进一步扩展到访问肽、药物的后期功能化和对映体富集的氨基酸。

  DOI：

  10.1021/acs.orglett.1c01781
• 作为产物：
  描述：

  乙酸酐 、 DL-2-氨基-3-苯基-1-丙醇 在 amberlyst-15 作用下， 以 苯 为溶剂， 反应 1.0h， 以77.1%的产率得到2-amino-3-phenyl-propanol-1-acetate
  参考文献：
  名称：

  Convenient and Selective Acetylations of Phenols, Amines and Alcohols

  摘要：

  Two convenient methods have been developed for selective acetylation. In method 1, phenols and amines are selectively acetylated in the presence of alcohols by acetic anhydride in a biphasic aqueous NaOH-isopropanol mixture. In method 2, alcoholic group is acetylated in the presence of amino functions using a strong acidic resin.

  DOI：

  10.1080/00397919208021671

文献信息

• AMINOCARBONYLCARBAMATE COMPOUNDS
  申请人：SK BIOPHARMACEUTICALS CO., LTD.

  公开号：US20150246874A1

  公开（公告）日：2015-09-03

  The present disclosure provides a compound represented by Formula (I) and a pharmaceutically acceptable salt which are effective as a dopamine reuptake inhibitor and a method of using the compound: wherein X is independently halo, alkyl, alkoxy or nitro; m is 0, 1, 2, 3 or 4; n is 1 or 2; R 1 and R 2 are independently H— or alkyl; R 3 is H—, alkyl or aralkyl; and R 4 is H— or aryl.

  本公开提供一种由化学式（I）表示的化合物和一种药用可接受的盐，作为多巴胺再摄取抑制剂，并提供了使用该化合物的方法：其中X分别是卤素，烷基，烷氧基或硝基；m为0, 1, 2, 3或4；n为1或2；R1和R2分别是H-或烷基；R3是H-，烷基或芳基烷基；R4是H-或芳基。
• PHENYLALKYLAMINO CARBAMATE COMPOSITIONS
  申请人：Pandey Ramendra N.

  公开号：US20080090902A1

  公开（公告）日：2008-04-17

  The present invention relates to a composition of a phenylalkylamino carbamate compound that results in improved stability, wherein the composition comprises a phenylalkylamino carbamate compound in a mixture with an effective amount of one or more excipients wherein at least one excipient is dibasic calcium phosphate dihydrate.

  本发明涉及一种苯基烷基氨基甲酸酯化合物的组合物，其结果是具有改善稳定性，其中该组合物包括苯基烷基氨基甲酸酯化合物与一种或多种有效量的赋形剂混合物，其中至少一种赋形剂是二碳酸钙二水合物。
• Synthesis of Benzoazepinone Derivatives via Photoredox Deaminative Radical Cascade Alkylation of 1,7-Dienes and 1,7-Enynes
  作者：José Tiago M. Correia、Márcio W. Paixão、Wanderson C. de Souza、Rafaely N. Lima、Iva S. de Jesus

  DOI：10.1055/a-1953-1849

  日期：2023.3

  A deaminative alkyl radical cascade cyclization of 1,7-dienes is described under visible-light photocatalysis. This method delivers a family of benzoazepinones (benzazepinones) and occurs under mild reaction conditions to access a broad substrate scope with excellent functional group tolerance and good yields. This protocol has also been extended to 1,7-enynes, furnishing a representative collection

  在可见光光催化下描述了 1,7-二烯的脱氨基烷基自由基级联环化。该方法提供了一系列苯并氮杂酮 (benzazepinones)，并在温和的反应条件下发生，以获得广泛的底物范围，具有出色的官能团耐受性和良好的产率。该协议还扩展到 1,7-enynes，提供了具有代表性的 cyclopentaquinolinones 集合。
• Convenient and Selective Acetylations of Phenols, Amines and Alcohols
  作者：Vandana Srivastava、Amita Tandon、Suprabhat Ray

  DOI：10.1080/00397919208021671

  日期：1992.9

  Two convenient methods have been developed for selective acetylation. In method 1, phenols and amines are selectively acetylated in the presence of alcohols by acetic anhydride in a biphasic aqueous NaOH-isopropanol mixture. In method 2, alcoholic group is acetylated in the presence of amino functions using a strong acidic resin.
• Adjunctive Therapy for Depression
  申请人：Sporn Jonathan

  公开号：US20080039529A1

  公开（公告）日：2008-02-14

  This invention is directed to a method of treating depression in a subject, comprising the step of administering a therapeutically effective amount of a conventional antidepressant and, in addition, administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member Rx selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R 1 and R 2 can be the same or different each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R 1 and R 2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.