4-Hydroxy-2,2-diphenyl-buttersaeure | 960-01-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Hydroxy-2,2-diphenyl-buttersaeure
• 英文别名: 2,2-Diphenyl-4-hydroxybutyric acid；4-hydroxy-2,2-diphenylbutanoic acid
• CAS: 960-01-0
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.301
• InChiKey: KZALBFMKMGNMAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Hydroxy-2,2-diphenyl-buttersaeure 在 氢溴酸 作用下， 以 水 为溶剂， 生成 双苯溴丁酸
  参考文献：
  名称：

  用 CO2 对苯乙烯氧化物进行直接和选择性电羧化获得 β-羟基酸

  摘要：

  描述了在未分裂的电池中用 CO 2对环氧化物进行高选择性和直接的还原性开环羧化，以产生合成重要的β-羟基酸。CO 2不仅在该反应中充当羧化试剂，而且还充当促进剂以在无添加剂的电化学条件下实现环氧化物的有效和化学选择性转化。

  DOI：

  10.1002/anie.202207660
• 作为产物：
  描述：

  α,α-二苯基-γ-丁内酯 在 alkaline solution 作用下， 生成 4-Hydroxy-2,2-diphenyl-buttersaeure
  参考文献：
  名称：

  Salmon-Legagneur, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1948, vol. 227, p. 437

  摘要：

  DOI：

文献信息

• Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots.
  申请人：Van Scott, Eugene J., Dr.

  公开号：EP0273202A2

  公开（公告）日：1988-07-06

  Composition and method for enhancing therapeutic effects of topically applied agents are disclosed. The cosmetic or therapeutic composition may include one or more of cosmetic or pharmaceutical agents present in a total amount of from 0.01 to 40 percent and one or more of hydroxycarboxylic acids or related compounds present in a total amount of from 0.01 to 99 percent by weight of the total composition. The cosmetic and pharmaceutical agents may include but not limited to age spots, wrinkles and keratoses removing agents; vitamins; aloes; sun screens; tanning, depigmenting and shampooing agents; antiyeasts; antifungal, antibacterial and antiviral agents; topical bronchial dilators and topical cardiovascular agents; hormonal agents; vasodilators; retinoids and other dermatological agents. The hydroxycarboxylic acids and related compounds include organic alpha and beta hydroxycarboxylic acids, alpha and beta ketocarboxylic acids and salts thereof. Topical application of the cosmetic or therapeutic compostion has been found to achieve a substantial increase in cosmetic or therapeutic effect of the active ingredient in humans and domesticated animals.

  本发明公开了增强外用药剂治疗效果的组合物和方法。该化妆品或治疗组合物可包括一种或多种化妆品或药物制剂，其总量为组合物总重量的 0.01% 至 40%，以及一种或多种羟基羧酸或相关化合物，其总量为组合物总重量的 0.01% 至 99%。化妆品和药物制剂可包括但不限于老年斑、皱纹和角化去除剂；维生素；芦荟；防晒霜；美黑、脱色和洗发剂；抗酵母菌；抗真菌、抗细菌和抗病毒剂；局部支气管扩张剂和局部心血管制剂；激素制剂；血管扩张剂；维甲酸和其他皮肤病制剂。羟基羧酸及相关化合物包括有机 alpha 和 beta 羟基羧酸、alpha 和 beta 酮羧酸及其盐类。研究发现，局部施用美容或治疗复合剂可大幅提高活性成分对人类和驯养动物的美容或治疗效果。
• Additives enhancing topical actions of therapeutic agents
  申请人：Van Scott, Eugene J., Dr.

  公开号：EP0599819A2

  公开（公告）日：1994-06-01

  Composition and method for enhancing therapeutic effects of topically applied agents are disclosed. The cosmetic or therapeutic composition may include one or more of cosmetic or pharmaceutical agents present in a total amount of from 0.01 to 40 percent and one or more of hydroxycarboxylic acids or related compounds present in a total amount of from 0.01 to 99 percent by weight of the total composition. The cosmetic and pharmaceutical agents may include but not limited to age spots, wrinkles and keratoses removing agents; vitamins; aloes; sun screens; tanning, depigmenting and shampooing agents; antiyeasts; antifungal, antibacterial and antiviral agents; topical bronchial dilators and topical cardiovascular agents; hormonal agents; vasodilators; retinoids and other dermatological agents. The hydroxycarboxylic acids and related compounds include organic alpha and beta hydroxycarboxylic acids, alpha and beta ketocarboxylic acids and salts thereof. Topical application of the cosmetic or therapeutic composition has been found to achieve a substantial increase in cosmetic or therapeutic effect of the active ingredient in humans and domesticated animals.

  本发明公开了增强外用药剂治疗效果的组合物和方法。该化妆品或治疗组合物可包括一种或多种化妆品或药物制剂，其总量为组合物总重量的 0.01% 至 40%，以及一种或多种羟基羧酸或相关化合物，其总量为组合物总重量的 0.01% 至 99%。化妆品和药物制剂可包括但不限于老年斑、皱纹和角化去除剂；维生素；芦荟；防晒霜；美黑、脱色和洗发剂；抗酵母菌；抗真菌、抗细菌和抗病毒剂；局部支气管扩张剂和局部心血管制剂；激素制剂；血管扩张剂；维甲酸和其他皮肤病制剂。羟基羧酸及相关化合物包括有机 alpha 和 beta 羟基羧酸、alpha 和 beta 酮羧酸及其盐类。研究发现，局部使用化妆品或治疗组合物可大大提高活性成分对人类和驯养动物的美容或治疗效果。
• COSMETIC COMPOSIIONS
  申请人：——

  公开号：US20010009674A1

  公开（公告）日：2001-07-26

  Cosmetic compoaition for topical application to the skin comprising a hydroxyalkyl cyclodextrin, salicylic acid or salicylic acid derivative and water. The compositions herein provide improved anti-acne/anti-inflammatory activity together with reduced skin irritation.

  用于皮肤局部涂抹的化妆品组合物，由羟烷基环糊精、水杨酸或水杨酸衍生物和水组成。这些组合物具有更好的抗痘/消炎活性，并能减少对皮肤的刺激。
• Topical treatment of ocular hypertension, glaucoma, ischemic retinopathy and age-related macular degeneration with ophthalmic formulation of dopamine antagonists
  申请人：——

  公开号：US20030069232A1

  公开（公告）日：2003-04-10

  This invention provides ocular formulations comprising an ocular drug and a carboxylic acid in an amount sufficient to maintain the pH of the formulation from about 4.5 to about 7.5. The ocular drug may be a dopamine antagonist and the acid may be lactic acid, citric acid or tartaric acid. In some aspects, the pH of the formulation is about 5.5 The ocular formulations of this invention provide enhanced bioavailability which results in increased drug concentrations across the cornea and in the eye ball, i.e., aqueous humor and intraocular organs and chambers. Moreover, the present formulations are non-irritating when applied topically and have a shelf-life of at least fourteen days at 25° C. Methods are also provided to increase ocular blood flow by using present ocular formulations comprising dopamine antagonists or other drugs for the prevention and treatment of ocular hypertension, glaucoma, ischemic retinopathy and age-related macular degeneration (AMD).

  本发明提供的眼用制剂包含一种眼用药物和一种羧酸，其用量足以将制剂的 pH 值保持在约 4.5 至约 7.5 之间。眼用药物可以是多巴胺拮抗剂，酸可以是乳酸、柠檬酸或酒石酸。在某些方面，制剂的 pH 值约为 5.5。本发明的眼用制剂提高了生物利用度，从而增加了角膜和眼球（即房水和眼内器官及腔室）中的药物浓度。此外，本发明制剂在局部使用时无刺激性，在 25° C 下的保质期至少为 14 天。本发明还提供了通过使用包含多巴胺拮抗剂或其他药物的本发明眼用制剂来增加眼血流量的方法，以预防和治疗眼压过高、青光眼、缺血性视网膜病变和老年性黄斑变性（AMD）。
• Lactones as new oxygenate fuel additives, fuels based thereon and methods for using same
  申请人：Robinson Michael J.

  公开号：US20060096158A1

  公开（公告）日：2006-05-11

  A new oxygenated fuel additive is disclosed, where the additive is a cyclic ester or lactone. A fuel including the new oxygenated fuel additive is disclosed, where the additive is a cyclic ester or lactone. A method is also disclosed for increasing the efficiency of engines and other combustion devices which burn fuels including the the new oxygenated fuel additive is disclosed, where the additive is a cyclic ester or lactone.

  公开了一种新型含氧燃料添加剂，其中的添加剂为环酯或内酯。公开了一种包括新型含氧燃料添加剂的燃料，其中的添加剂是一种环酯或内酯。本发明还公开了一种方法，用于提高燃烧包括本发明公开的新型含氧燃料添加剂的燃料的发动机和其他燃烧装置的效率，其中添加剂为环酯或内酯。