N-cyclohexyl-2-(4-methylphenylsulfonamido)benzamide | 864388-17-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-cyclohexyl-2-(4-methylphenylsulfonamido)benzamide
• 英文别名: N-cyclohexyl-2-[(4-methylphenyl)sulfonylamino]benzamide
• CAS: 864388-17-0
• 化学式: C₂₀H₂₄N₂O₃S
• 分子量: 372.488
• InChiKey: GBWLQBWXXZFZRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对甲苯磺酰氯 在 sodium azide 、 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 双三氟甲烷磺酰亚胺银盐 作用下， 以 水 、 1,2-二氯乙烷 、 丙酮 为溶剂， 反应 23.0h， 生成 N-cyclohexyl-2-(4-methylphenylsulfonamido)benzamide
  参考文献：
  名称：

  钌催化直接Ç ？芳烃的H酰胺化，包括弱配位的芳香酮

  摘要：

  Ç  ħ激活：所述的钌催化直接SP 2 ç  ħ酰胺化，通过使用叠氮化物磺酰作为氨基源被呈现（参见方案）的芳烃。各种基材容易酰胺化，包括带有弱配位基团的芳烃。由此获得的产物的合成效用在生物活性杂环的制备中得到证明。

  DOI：

  10.1002/chem.201301025

文献信息

• Iridium-catalyzed <i>ortho</i>-selective carbon–hydrogen amidation of benzamides with sulfonyl azides in ionic liquid
  作者：Lin-Yu Jiao、Zi-Hui Ning、Qian Hong、Xin-Hua Peng、Xiao-Mei Yin、Shanshan Liu、Huiyong Chen、Zhuo Li、Ming Sun、Xiao-Xun Ma

  DOI：10.1039/d0ra05527a

  日期：——

  An efficient and convenient iridium(III) catalyzed ortho-C–H bond amidation of weakly coordinating benzamides treated with readily available sulfonyl azides as the amino source has been described. In this transformation, ionic liquids represents an ideal reaction medium, giving rise to a broad range of amidation products under mild conditions in the open air. This protocol offers moderate to excellent

  已经描述了用容易获得的磺酰叠氮化物作为氨基源处理的弱配位苯甲酰胺的有效且方便的铱( III )催化邻-C-H键酰胺化。在这种转变中，离子液体代表了一种理想的反应介质，在温和的露天条件下可产生多种酰胺化产物。该协议提供中等至优异的化学产量、独特的区域选择性和良好的官能团耐受性。
• Inhibitors of oplophorus luciferase-derived bioluminescent complexes
  申请人：PROMEGA CORPORATION

  公开号：US11390599B2

  公开（公告）日：2022-07-19

  Compounds that may selectively inhibit Oplophorus luciferase-derived bioluminescent complexes, e.g., NanoBiT® bioluminescent complex, are disclosed as well as compositions and kits comprising the compounds, and methods of using the compounds.

  公开了可选择性抑制 Oplophorus 荧光素酶衍生的生物发光复合物（如 NanoBiT® 生物发光复合物）的化合物，以及包含这些化合物的组合物和试剂盒，以及使用这些化合物的方法。
• Iridium-Catalyzed Direct Arene C–H Bond Amidation with Sulfonyl- and Aryl Azides
  作者：Donggun Lee、Youngchan Kim、Sukbok Chang

  DOI：10.1021/jo4019683

  日期：2013.11.1

  Iridium-catalyzed direct ortho C-H amidation of arenes has been shown to work well with sulfonyl- and aryl azides as the nitrogen source. The reaction proceeds efficiently with a broad range of substrates bearing conventional directing groups with excellent functional group compatibility under mild conditions. In addition, substrates forming not only 5- but also 6-membered iridacycle intermediates undergo the C-H amidation with high selectivity.
• INHIBITORS OF OPLOPHORUS LUCIFERASE-DERIVED BIOLUMINESCENT COMPLEXES
  申请人：Promega Corporation

  公开号：EP3802514A1

  公开（公告）日：2021-04-14
• Ruthenium-Catalyzed Direct CH Amidation of Arenes Including Weakly Coordinating Aromatic Ketones
  作者：Jiyu Kim、Jinwoo Kim、Sukbok Chang

  DOI：10.1002/chem.201301025

  日期：2013.6.3

  CH activation: The ruthenium‐catalyzed direct sp2 CH amidation of arenes by using sulfonyl azides as the amino source is presented (see scheme). A wide range of substrates were readily amidated including arenes bearing weakly coordinating groups. Synthetic utility of the thus obtained products was demonstrated in the preparation of biologically active heterocycles.

  Ç  ħ激活：所述的钌催化直接SP 2 ç  ħ酰胺化，通过使用叠氮化物磺酰作为氨基源被呈现（参见方案）的芳烃。各种基材容易酰胺化，包括带有弱配位基团的芳烃。由此获得的产物的合成效用在生物活性杂环的制备中得到证明。