ethyl (all-Z)-2-ethoxy-9,12,15-octadecatrienoate | 1022975-77-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl (all-Z)-2-ethoxy-9,12,15-octadecatrienoate
• 英文别名: ethyl (9Z,12Z,15Z)-2-ethoxyoctadeca-9,12,15-trienoate
• CAS: 1022975-77-4
• 化学式: C₂₂H₃₈O₃
• 分子量: 350.542
• InChiKey: OOPDORTUQAGVSX-JPFHKJGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  25
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl (all-Z)-2-hydroxy-9,12,15-octadecatrienoate 、 碘乙烷 在 potassium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以24%的产率得到ethyl (all-Z)-2-ethoxy-9,12,15-octadecatrienoate
  参考文献：
  名称：

  WO2008/53331

  摘要：

  公开号：

文献信息

• ALPHA-SUBSTITUTED OMEGA-3 LIPIDS THAT ARE ACTIVATORS OR MODULATORS OF THE PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR (PPAR)
  申请人：Bryhn Morten

  公开号：US20100035990A1

  公开（公告）日：2010-02-11

  Omega-3 lipid compounds of the general formula (I): wherein R 1 and R 2 are the same or different and may be selected from a group of substituents consisting of hydrogen, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, a carboxy group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; X represents a carboxylic acid or a derivative thereof, a carboxylate, a carboxylic anhydride or a carboxamide; and Y is a C 6 to C 22 alkene with two or more double bonds, having E and/or Z configuration, are disclosed. Also disclosed are pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments in particular for the treatment of cardiovascular and metabolic diseases.
• US8399516B2
  申请人：——

  公开号：US8399516B2

  公开（公告）日：2013-03-19
• [EN] A COMBINATION PRODUCT COMPRISING AT LEAST ONE LIPID SUBSTITUTED IN THE ALPHA POSITION AND AT LEAST ONE HYPOGLYCEMIC AGENT<br/>[FR] PRODUIT DE COMBINAISON COMPRENANT AU MOINS UN LIPIDE SUBSTITUÉ EN POSITION ALPHA ET AU MOINS UN AGENT HYPOGLYCÉMIQUE
  申请人：PRONOVA BIOPHARMA NORGE AS

  公开号：WO2008053340A1

  公开（公告）日：2008-05-08

  [EN] A combination product comprising: at least one lipid in the form of a carboxylic acid, or a derivative thereof, a carboxylic ester, a carboxylic anhydride, an alcohol or an amide, which lipid is substituted at carbon 2, counted from the functional group, with at least one substituent, or any pharmaceuticlly acceptable complex, salt, solvate or pro-drug thereof; and at least one hypoglycemic agent, or any pharmaceuticlly acceptable complex, solvate or pro-drug thereof, is disclosed. Also disclosed is the use of such a combination product for the treatment of diabetic conditions.
  [FR] Produit de combinaison comprenant: au moins un lipide sous la forme d'acide carboxylique, ou un dérivé correspondant, un ester carboxylique, un anhydride carboxylique, un alcool ou un amide, ce lipide substitué à l'atome de carbone 2, compté à partir du groupe fonctionnel, avec au moins un substituant, ou un complexe, sel, solvate ou promédicament correspondant pharmaceutiquement acceptable; et au moins un agent hypoglycémique ou un complexe, solvate ou promédicament correspondant pharmaceutiquement acceptable. Également, utilisation de ce produit de combinaison pour le traitement d'affections diabétiques.
• WO2008/53331
  申请人：——

  公开号：——

  公开（公告）日：——