Phenyl-(2-phenylaminomethyl-4,5-dihydro-imidazol-1-yl)-methanone | 166904-42-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phenyl-(2-phenylaminomethyl-4,5-dihydro-imidazol-1-yl)-methanone
• 英文别名: [2-(Anilinomethyl)-4,5-dihydroimidazol-1-yl]-phenylmethanone
• CAS: 166904-42-3
• 化学式: C₁₇H₁₇N₃O
• 分子量: 279.341
• InChiKey: IDRCHUQDKHXQDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  44.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Phenyl-(2-phenylaminomethyl-4,5-dihydro-imidazol-1-yl)-methanone 在 水 作用下， 以 丙酮 为溶剂， 反应 0.33h， 以68%的产率得到N-phenylglycine-2-benzamidoethylamide
  参考文献：
  名称：

  Aminoamidines

  摘要：

  2-(Arylaminomethyl)imidazolines were prepared by the reaction of arylaminoacetonitriles with ethylenediamine in the presence of catalytic amounts of P2S5 These imidazolines react with aroyl chlorides (1 : 2 ratio) to give diacylation products. In the case of a 1 : 1 mole ratio as well as on treatment with Ac2O in Et(3)N, monoacylation at the imidazoline ring predominantly occurs. Isomeric 2-(N-benzoyl-N-arylaminomethyl)imidazolines were obtained from N-benzoyl-N-arylaminoacetonitriles by the Pinner method. 2-(N-Aroyl-N-arylaminomethyl)benzimidazoles and -benzoxazoles were synthesized in a similar way.

  DOI：

  10.1007/bf01169722
• 作为产物：
  描述：

  非那唑啉 、 苯甲酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以58%的产率得到Phenyl-(2-phenylaminomethyl-4,5-dihydro-imidazol-1-yl)-methanone
  参考文献：
  名称：

  Aminoamidines

  摘要：

  2-(Arylaminomethyl)imidazolines were prepared by the reaction of arylaminoacetonitriles with ethylenediamine in the presence of catalytic amounts of P2S5 These imidazolines react with aroyl chlorides (1 : 2 ratio) to give diacylation products. In the case of a 1 : 1 mole ratio as well as on treatment with Ac2O in Et(3)N, monoacylation at the imidazoline ring predominantly occurs. Isomeric 2-(N-benzoyl-N-arylaminomethyl)imidazolines were obtained from N-benzoyl-N-arylaminoacetonitriles by the Pinner method. 2-(N-Aroyl-N-arylaminomethyl)benzimidazoles and -benzoxazoles were synthesized in a similar way.

  DOI：

  10.1007/bf01169722

文献信息

• Insecticidal Substituted Aminoalkyl Heterocyclic and Heteroaryl Derivatives
  申请人：Dixson John A.

  公开号：US20090209422A1

  公开（公告）日：2009-08-20

  Certain substituted aminoalkyl heteroaryl and heterocyclyl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein R, R 1 , R 2 , R 3 and R 4 are folly described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of an additional compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  某些取代氨基烷基杂芳基和杂环基衍生物提供了意外的杀虫和杀螨活性。这些化合物由公式I表示：其中R，R1，R2，R3和R4在此完整描述。此外，还公开了包含公式I中至少一种化合物的杀虫有效量和可选地至少一种其他化合物的有效量，以及至少一种杀虫兼容载体的组合物；以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的地点。
• INSECTICIDAL SUBSTITUTED AMINOALKYL HETEROCYCLIC AND HETEROARYL DERIVATIVES
  申请人：Bayer CropScience AG

  公开号：EP1879455A1

  公开（公告）日：2008-01-23
• [EN] INSECTICIDAL SUBSTITUTED AMINOALKYL HETEROCYCLIC AND HETEROARYL DERIVATIVES<br/>[FR] DERIVES AMINOALKYLES HETEROCYCLIQUES ET HETEROARYLES SUBSTITUES INSECTICIDES
  申请人：FMC CORP

  公开号：WO2006119411A1

  公开（公告）日：2006-11-09

  [EN] Certain substituted aminoalkyl heteroaryl and heterocyclyl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein R, R¹, R², R³ and R⁴ are folly described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of an additional compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
  [FR] Certains dérivés aminoalkyles hétéroaryles et hétérocycliques substitués ont révélé une activité insecticide et acaricide inattendue. Ces composés sont représentés par la formule (I) dans laquelle R, R¹, R², R³ et R⁴ sont entièrement décrits. L'invention se rapporte également à des compositions comprenant une dose insecticide efficace d'au moins un composé de formule (I), et éventuellement, une dose efficace d'au moins un composé additionnel, et au moins un support compatible insecticide ; l'invention concerne également des procédés permettant de combattre les insectes et qui consistent à appliquer lesdites compositions sur un site où les insectes sont présents ou susceptibles de l'être.
• Aminoamidines
  作者：E. E. Korshin、L. I. Sabirova、A. G. Akhmadullin、Ya. A. Levin

  DOI：10.1007/bf01169722

  日期：1994.3

  2-(Arylaminomethyl)imidazolines were prepared by the reaction of arylaminoacetonitriles with ethylenediamine in the presence of catalytic amounts of P2S5 These imidazolines react with aroyl chlorides (1 : 2 ratio) to give diacylation products. In the case of a 1 : 1 mole ratio as well as on treatment with Ac2O in Et(3)N, monoacylation at the imidazoline ring predominantly occurs. Isomeric 2-(N-benzoyl-N-arylaminomethyl)imidazolines were obtained from N-benzoyl-N-arylaminoacetonitriles by the Pinner method. 2-(N-Aroyl-N-arylaminomethyl)benzimidazoles and -benzoxazoles were synthesized in a similar way.