4-ethoxy-N-(2-iodophenyl)benzamide | 333348-82-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-ethoxy-N-(2-iodophenyl)benzamide
• CAS: 333348-82-6
• 化学式: C₁₅H₁₄INO₂
• mdl: MFCD01216137
• 分子量: 367.186
• InChiKey: GIGNNUJROGAGEF-UHFFFAOYSA-N

物化性质

• 沸点：
  372.2±27.0 °C(Predicted)
• 密度：
  1.590±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-ethoxy-N-(2-iodophenyl)benzamide 在 copper acetylacetonate 、 乙醇 、 二乙胺 、 vasicine 作用下， 反应 12.0h， 以85%的产率得到4-乙氧基-N-苯基苯甲酰胺
  参考文献：
  名称：

  Exploration of Cu-catalyzed regioselective hydrodehalogenation of o-haloanilides using EtOH as hydrogen source

  摘要：

  DOI：

  10.1016/j.jorganchem.2021.121844

文献信息

• Efficient Cu-catalyzed intramolecular <i>O</i>-arylation for synthesis of benzoxazoles in water
  作者：Yanling Tang、Minxin Li、Hui Gao、Gaoxiong Rao、Zewei Mao

  DOI：10.1039/d0ra00570c

  日期：——

  An efficient method was developed for synthesis of benzoxazoles by Cu-catalyzed intramolecular O-arylation of o-halobenzanilides in water. This strategy provides several advantages, such as high yields, water as a green solvent and functional groups tolerance.

  开发了一种通过铜催化的邻卤代苯甲酰苯胺在水中的分子内O-芳基化合成苯并恶唑的有效方法。这种策略提供了几个优点，例如高产率、水作为绿色溶剂和官能团耐受性。
• Copper-catalyzed regioselective 2-amination of o-haloanilides with aqueous ammonia
  作者：Yan-Ling Tang、Mei-Ling Li、Jin-Chun Gao、Yun Sun、Lu Qu、Feng Huang、Ze-Wei Mao

  DOI：10.1016/j.tetlet.2021.153001

  日期：2021.4

  An efficient Cu(II)-vasicine catalytic system has been developed for intramolecular CN bond formation. In this way, regioselective 2-amination of o-haloanilides with aqueous ammonia in EtOH has been achieved. This strategy provides several advantages, such as good regioselectivity, high yields and functional group tolerance.

  已经开发出用于分子内C N键形成的有效Cu（II）-水杨碱催化体系。以这种方式，已经实现了在EtOH中用氨水进行邻卤代苯胺的区域选择性2-胺化。该策略具有几个优点，例如良好的区域选择性，高产率和官能团耐受性。
• Synthesis of N-aroyl-2-arylindoles using solid calcium carbide as an alkyne source instead of gaseous acetylene
  作者：Qian Wang、Zheng Li

  DOI：10.1016/j.tet.2023.133548

  日期：2023.8

  synthesis of N-aroyl-2-arylindoles by reactions of 2 mol of various N-(2-iodoaryl)arylamides with 1 mol of calcium carbide through one-step procedure is described. This protocol has the salient features of the use of an inexpensive, abundant and easy-to-handle solid calcium carbide instead of flammable and explosive gaseous acetylene as an original alkyne source. In addition, wide scope of substrates, satisfactory

  描述了一种通过 2 mol 各种N- (2-碘芳基)芳酰胺与 1 mol 电石一步反应合成N-芳酰基-2-芳基吲哚的有效方法。该方案的显着特点是使用廉价、丰富且易于处理的固体碳化钙代替易燃易爆的气态乙炔作为原始炔烃源。此外，底物范围广、产率令人满意、后处理程序简单也是该方法的优点。
• Exploration of Cu-catalyzed regioselective hydrodehalogenation of o-haloanilides using EtOH as hydrogen source
  作者：Min-Xin Li、Mei-Ling Li、Yan-Ling Tang、Yun Sun、Lu Qu、Feng Huang、Ze-Wei Mao

  DOI：10.1016/j.jorganchem.2021.121844

  日期：2021.6