6'-(2-Thienyl)-2,2':4',4''-terpyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6'-(2-Thienyl)-2,2':4',4''-terpyridine
• 英文别名: 2-pyridin-2-yl-4-pyridin-4-yl-6-thiophen-2-ylpyridine
• 化学式: C₁₉H₁₃N₃S
• 分子量: 315.398
• InChiKey: WDHTXVDOBUFUHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-[2-氧-2-(2-吡啶基)乙基]碘化吡啶 、 1-(Thiophen-2-yl)-3-(4-pyridinyl)-2-propene-1-one 在 乙酸铵 作用下， 以 甲醇 为溶剂， 生成 6'-(2-Thienyl)-2,2':4',4''-terpyridine
  参考文献：
  名称：

  2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship

  摘要：

  Designed and synthesized were a series of pyridines substituted at 2, 4, and 6 positions with various 5- or 6-memberd heteroaromatics as antitumor agents. They were evaluated their topoisomerase I and II inhibitory activities along with cytotoxicities against several human cancer cell lines. Among the prepared compounds, 10-20 showed significant topoisomerase I or II inhibitory activities, and 21-26 showed considerable cytotoxicities against several human cancer cell lines. Structure-activity relationship study indicates that 4-pyridine at 6-position of central pyridine plays a key role in biological activity. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.04.047

文献信息

• 2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship
  作者：Arjun Basnet、Pritam Thapa、Radha Karki、Younghwa Na、Yurngdong Jahng、Byeong-Seon Jeong、Tae Cheon Jeong、Chong-Soon Lee、Eung-Seok Lee

  DOI：10.1016/j.bmc.2007.04.047

  日期：2007.7

  Designed and synthesized were a series of pyridines substituted at 2, 4, and 6 positions with various 5- or 6-memberd heteroaromatics as antitumor agents. They were evaluated their topoisomerase I and II inhibitory activities along with cytotoxicities against several human cancer cell lines. Among the prepared compounds, 10-20 showed significant topoisomerase I or II inhibitory activities, and 21-26 showed considerable cytotoxicities against several human cancer cell lines. Structure-activity relationship study indicates that 4-pyridine at 6-position of central pyridine plays a key role in biological activity. (c) 2007 Elsevier Ltd. All rights reserved.