anilino(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)acetonitrile | 1260237-23-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: anilino(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)acetonitrile
• 英文别名: 2-Anilino-2-(2,5-dimethyl-1-phenylpyrrol-3-yl)acetonitrile
• CAS: 1260237-23-7
• 化学式: C₂₀H₁₉N₃
• 分子量: 301.391
• InChiKey: NLDZKWLEKZDSBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  40.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三甲基氰硅烷 、 1-(2,5-二甲基-1-苯基-1H-吡咯-3-基)乙烷-1-酮 、 苯胺 以 水 为溶剂， 反应 12.0h， 以92%的产率得到anilino(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)acetonitrile
  参考文献：
  名称：

  Water-Mediated Strecker Reaction: An Efficient and Environmentally Friendly Approach for the Synthesis of α-Aminonitriles via a Three-Component Condensation

  摘要：

  The synthesis of -aminonitriles by a direct three component Strecker reaction has been achieved in water, which is found to be an inexpensive, non-toxic and eco-friendly reaction medium for the nucleophilic addition. This protocol is effective to a wide variety of substrates with different functional groups and does not require the use any other catalyst.

  DOI：

  10.1080/00397910903457381

文献信息

• Water-Mediated Strecker Reaction: An Efficient and Environmentally Friendly Approach for the Synthesis of <font>α</font>-Aminonitriles <i>via</i> a Three-Component Condensation
  作者：Samikannu Ramesh、Kulanthaivel Sivakumar、Chiradeep Panja、Pirama Nayagam Arunachalam、Appaswami Lalitha

  DOI：10.1080/00397910903457381

  日期：2010.11.3

  The synthesis of -aminonitriles by a direct three component Strecker reaction has been achieved in water, which is found to be an inexpensive, non-toxic and eco-friendly reaction medium for the nucleophilic addition. This protocol is effective to a wide variety of substrates with different functional groups and does not require the use any other catalyst.