Fmoc-Lys-Gly-Gly-OBn | 369649-09-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fmoc-Lys-Gly-Gly-OBn
• 英文别名: benzyl 2-[[2-[[(2S)-6-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoyl]amino]acetyl]amino]acetate
• CAS: 369649-09-2
• 化学式: C₃₂H₃₆N₄O₆
• 分子量: 572.661
• InChiKey: NORQFBQWICKHRW-NDEPHWFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  42
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  149
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Fmoc-Lys-Gly-Gly-OBn 在 palladium on activated charcoal 氢气 、 N,N-二异丙基乙胺 、 N,N'-羰基二咪唑 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 Fmoc-L-Lys[2-(2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl)acetamide]-Gly-Gly-OH
  参考文献：
  名称：

  Synthesis of a C-linked Antifreeze Glycoprotein (AFGP) Mimic:  Probes for Investigating the Mechanism of Action

  摘要：

  [GRAPHICS]A general convergent synthesis has been developed to afford a low molecular weight C-linked antifreeze glycoprotein (AFGP) mimic (9). Structural mimics of AFGPs have tremendous potential as probes to better understand how native AFGPs inhibit ice crystal growth in organisms that inhabit subzero environments.

  DOI：

  10.1021/ol991025+
• 作为产物：
  描述：

  {2-[(S)-6-tert-Butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoylamino]-acetylamino}-acetic acid benzyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 Fmoc-Lys-Gly-Gly-OBn
  参考文献：
  名称：

  Synthesis of a C-linked Antifreeze Glycoprotein (AFGP) Mimic:  Probes for Investigating the Mechanism of Action

  摘要：

  [GRAPHICS]A general convergent synthesis has been developed to afford a low molecular weight C-linked antifreeze glycoprotein (AFGP) mimic (9). Structural mimics of AFGPs have tremendous potential as probes to better understand how native AFGPs inhibit ice crystal growth in organisms that inhabit subzero environments.

  DOI：

  10.1021/ol991025+

文献信息

• Synthesis of a C-linked Antifreeze Glycoprotein (AFGP) Mimic:  Probes for Investigating the Mechanism of Action
  作者：Robert N. Ben、Adewale A. Eniade、Lisa Hauer

  DOI：10.1021/ol991025+

  日期：1999.12.1

  [GRAPHICS]A general convergent synthesis has been developed to afford a low molecular weight C-linked antifreeze glycoprotein (AFGP) mimic (9). Structural mimics of AFGPs have tremendous potential as probes to better understand how native AFGPs inhibit ice crystal growth in organisms that inhabit subzero environments.