8-Azido-5,6-二氢-5-甲基-6-氧代-4H-咪唑并[1,5-a][1,4]苯并二氮杂-3-羧酸乙酯 | 91917-65-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 中文名称: 8-Azido-5,6-二氢-5-甲基-6-氧代-4H-咪唑并[1,5-a][1,4]苯并二氮杂-3-羧酸乙酯
• 英文名称: Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate
• 英文别名: ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
• CAS: 91917-65-6
• 化学式: C15H14N6O3
• 分子量: 326.31
• InChiKey: CFSOJZTUTOQNIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  78.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Methods and compositions for treating a subject for central nervous system (CNS) injury
  申请人：Carmichael Stanley T.

  公开号：US10206921B2

  公开（公告）日：2019-02-19

  Methods for treating a central nervous system (CNS) injury in a subject are provided. Aspects of the methods include administering to the subject an effective amount of gamma aminobutyric acid (GABA) receptor signaling inhibitor to treat the subject for the CNS injury. Also provided are compositions finding use in embodiments of the methods. Methods and compositions of the invention find use in the treatment of a variety of different CNS injuries, including but not limited to, treating a subject for CNS injury associated with the occurrence of stroke.

  本文提供了治疗受试者中枢神经系统（CNS）损伤的方法。这些方法的各个方面包括向受试者施用有效量的γ-氨基丁酸（GABA）受体信号转导抑制剂，以治疗受试者的中枢神经系统损伤。此外，还提供了可用于本方法实施方案的组合物。本发明的方法和组合物可用于治疗各种不同的中枢神经系统损伤，包括但不限于治疗与中风发生相关的中枢神经系统损伤。
• METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME
  申请人：President and Fellows of Harvard College

  公开号：EP3468545A1

  公开（公告）日：2019-04-17
• METHODS AND COMPOSITIONS FOR TREATING A SUBJECT FOR CENTRAL NERVOUS SYSTEM (CNS) INJURY
  申请人：Carmichael Stanley T.

  公开号：US20110224278A1

  公开（公告）日：2011-09-15

  Methods for treating a central nervous system (CNS) injury in a subject are provided. Aspects of the methods include administering to the subject an effective amount of gamma aminobutyric acid (GABA) receptor signaling inhibitor to treat the subject for the CNS injury. Also provided are compositions finding use in embodiments of the methods. Methods and compositions of the invention find use in the treatment of a variety of different CNS injuries, including but not limited to, treating a subject for CNS injury associated with the occurrence of stroke.
• GABAA RECEPTOR ANTAGONISTS AFFECTING GANGLION CELL FUNCTION AND VISUAL ACUITY
  申请人：Allergan, Inc.

  公开号：US20150025061A1

  公开（公告）日：2015-01-22

  The present invention is directed to a method of enhancing visual acuity in a subject, comprising intravitreally administering to the subject in need of such enhancement, a therapeutically effective amount of an extrasynaptic GABA A receptor antagonist. The present invention is also directed to an ocular implant comprising a therapeutically effective amount of the extrasynaptic GABA A receptor antagonist.
• [EN] METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR RÉDUIRE LE DYSFONCTIONNEMENT TACTILE ET L'ANXIÉTÉ ASSOCIÉS AU TROUBLE DU SPECTRE DE L'AUTISME, AU SYNDROME DE RETT ET AU SYNDROME DE L'X FRAGILE
  申请人：HARVARD COLLEGE

  公开号：WO2017214442A1

  公开（公告）日：2017-12-14

  The present invention features a method of reducing tactile dysfunction or anxiety in a subject diagnosed with Autism Spectrum Disorder, Rett Syndrome, or Fragile X syndrome by administering a GABAA agent having reduced blood brain barrier or by expressing a nucleic acid encoding an exogenous alpha or beta subunit of a GABAA receptor in dorsal root ganglion neurons in the subject using a vector.