2-<3-(4-Methylphenyl)propyl>furan | 109878-70-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-<3-(4-Methylphenyl)propyl>furan
• 英文别名: 1-(Fur-2'-yl)-3-p-tolylpropane；2-[3-(4-Methylphenyl)propyl]furan
• CAS: 109878-70-8
• 化学式: C₁₄H₁₆O
• 分子量: 200.28
• InChiKey: DSXHHVFXZSFMJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-<3-(4-Methylphenyl)propyl>furan 在 氘氧化钾 作用下， 生成
  参考文献：
  名称：

  Gas-phase deuterium exchange of fluorenes, furans, and thiophenes in the inlet system of a gas chromatograph/mass spectrometer

  摘要：

  Reaction columns containing a packing of KOD or D3PO4 in a stationary liquid phase on a support as components in a gas chromatograph/mass spectrometer were shown to provide selective basic H/D exchange of fluorenes and furans and acidic H/D exchange of thiophenes under gas-phase conditions. Such columns were proposed for use in the study of fragmentation mechanisms and establishment of the position of substituents in the ring.

  DOI：

  10.1007/bf00958015
• 作为产物：
  描述：

  2-呋喃丙烯醛 、 对溴甲苯 在 lithium sodium 、 氨 、 lithium 作用下， 生成 2-<3-(4-Methylphenyl)propyl>furan
  参考文献：
  名称：

  酰基杂环的串联芳基化还原。方便地合成苄基杂环† ‡

  摘要：

  使用苯基-，4-甲基苯基-和4-甲氧基-苯基锂试剂将一系列酰基杂环进行串联芳基化还原，然后将锂-氨-氯化铵还原，得到相应的苄基杂环。在这项研究中调查的酰基杂环化合物包括呋喃，2,3-二氢-4 H -1-苯并吡喃，4 H -1-苯并吡喃，噻吩，4,5,6,7-四氢苯并[ b ]噻吩，2,3-二氢-4 H -1-苯并噻喃和吡啶核。除了2，3-二氢-4 H -1-苯并噻吩并-4-酮外，所有酰基杂环均产生相应的苄基杂环，其在还原过程中选择性裂解，得到相应的2-（1-芳基丙基）苯硫醇。

  DOI：

  10.1002/jhet.5570240453

文献信息

• Dinuclear Iron Complex-Catalyzed Cross-Coupling of Primary Alkyl Fluorides with Aryl Grignard Reagents
  作者：Zhenbo Mo、Qiang Zhang、Liang Deng

  DOI：10.1021/om300722g

  日期：2012.9.24

  Iron-catalyzed cross-coupling of nonactivated primary alkyl fluorides with aryl Grignard reagents has been achieved by using the low-coordinate dinuclear iron complex [(IPr2Me2)Fe(μ2-NDipp)2Fe(IPr2Me2)] as the catalyst. This iron-catalyzed C(sp3)–F bond arylation reaction is applicable to a variety of aryl Grignard reagents and primary alkyl fluorides. The product pattern suggests the involvement of a

  铁-催化已经通过使用所获得的与芳基格氏试剂未活化伯烷基氟化物的交叉耦合的低坐标双核铁配合物[（IPR 2我2）的Fe（μ 2 -NDipp）2的Fe（IPR 2我2）]作为催化剂。这种铁催化的C（sp 3）–F键芳基化反应适用于各种芳基格氏试剂和伯烷基氟化物。产品模式表明，在其C–F键断裂步骤中涉及一种自由基类型的机制。
• Reaction chromato-spectrometry in the series of 1-aryl-2-(2-furyl) cyclopropanes
  作者：A. I. Mikaya、V. G. Zaikin、M. V. Tsodikov

  DOI：10.1007/bf00953340

  日期：1986.11
• HALL, STAN S.;FARAHAT, SAMI E., J. HETEROCYCL. CHEM., 24,(1987) N 4, 1205-1213
  作者：HALL, STAN S.、FARAHAT, SAMI E.

  DOI：——

  日期：——
• Gas-phase deuterium exchange of fluorenes, furans, and thiophenes in the inlet system of a gas chromatograph/mass spectrometer
  作者：A. I. Mikaya、G. D. Romanov、V. G. Zaikin

  DOI：10.1007/bf00958015

  日期：1991.3

  Reaction columns containing a packing of KOD or D3PO4 in a stationary liquid phase on a support as components in a gas chromatograph/mass spectrometer were shown to provide selective basic H/D exchange of fluorenes and furans and acidic H/D exchange of thiophenes under gas-phase conditions. Such columns were proposed for use in the study of fragmentation mechanisms and establishment of the position of substituents in the ring.
• Tandem arylation-reduction of acyl heterocycles. Convenient synthesis of benzyl heterocycles
  作者：Stan S. Hall、Sami E. Farahat

  DOI：10.1002/jhet.5570240453

  日期：1987.7

  arylation-reduction of a series of acyl heterocycles using phenyl-, 4-methylphenyl-, and 4-methoxy-phenyllithium reagents followed by lithium-ammonia-ammonium chloride reduction afforded the corresponding benzyl heterocycles. The acyl heterocycles surveyed in this study contained furan, 2,3-dihydro-4H-1-benzopyran, 4H-1-benzopyran, thiophene, 4,5,6,7-tetrahydrobenzo[b]thiophene, 2,3-dihydro-4H-1-benzothiopyran

  使用苯基-，4-甲基苯基-和4-甲氧基-苯基锂试剂将一系列酰基杂环进行串联芳基化还原，然后将锂-氨-氯化铵还原，得到相应的苄基杂环。在这项研究中调查的酰基杂环化合物包括呋喃，2,3-二氢-4 H -1-苯并吡喃，4 H -1-苯并吡喃，噻吩，4,5,6,7-四氢苯并[ b ]噻吩，2,3-二氢-4 H -1-苯并噻喃和吡啶核。除了2，3-二氢-4 H -1-苯并噻吩并-4-酮外，所有酰基杂环均产生相应的苄基杂环，其在还原过程中选择性裂解，得到相应的2-（1-芳基丙基）苯硫醇。