(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-yl)-methanol | 372107-04-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-yl)-methanol
• 英文别名: [1-Phenyl-3-(4-phenylphenyl)pyrazol-4-yl]methanol
• CAS: 372107-04-5
• 化学式: C₂₂H₁₈N₂O
• 分子量: 326.398
• InChiKey: OKPQTDUWEYAYBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-yl)-methanol 在 氯化亚砜 作用下， 以 苯 为溶剂， 反应 2.0h， 以75%的产率得到3-([1,1’-biphenyl]-4-yl)-4-(chloromethyl)-1-phenyl-1Hpyrazole
  参考文献：
  名称：

  摘要：

  3-Aryl(heteryl)pyrazole-4-carbaldehydes were reduced with sodium tetrahydridoborate under mild conditions to give 3-aryl(heteryl)-4-hydroxymethylpyrazoles which were converted into the corresponding 4-chloromethyl derivatives by treatment with thionyl chloride. The subsequent reaction with triphenylphosphine led to formation of triphenyl(4-pyrazolylmethyl)phosphonium chlorides, and Wittig reaction of the latter with aromatic or heteroaromatic aldehydes yielded 4-[2-aryl(heteryl)ethenyl]pyrazoles.

  DOI：

  10.1023/a:1016346528487
• 作为产物：
  描述：

  3-联苯-1-苯基-1H-吡唑-4-甲醛 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以81%的产率得到(3-Biphenyl-4-yl-1-phenyl-1H-pyrazol-4-yl)-methanol
  参考文献：
  名称：

  摘要：

  3-Aryl(heteryl)pyrazole-4-carbaldehydes were reduced with sodium tetrahydridoborate under mild conditions to give 3-aryl(heteryl)-4-hydroxymethylpyrazoles which were converted into the corresponding 4-chloromethyl derivatives by treatment with thionyl chloride. The subsequent reaction with triphenylphosphine led to formation of triphenyl(4-pyrazolylmethyl)phosphonium chlorides, and Wittig reaction of the latter with aromatic or heteroaromatic aldehydes yielded 4-[2-aryl(heteryl)ethenyl]pyrazoles.

  DOI：

  10.1023/a:1016346528487

文献信息

• ——
  作者：M. K. Bratenko、V. A. Chornous、M. V. Vovk

  DOI：10.1023/a:1016346528487

  日期：——

  3-Aryl(heteryl)pyrazole-4-carbaldehydes were reduced with sodium tetrahydridoborate under mild conditions to give 3-aryl(heteryl)-4-hydroxymethylpyrazoles which were converted into the corresponding 4-chloromethyl derivatives by treatment with thionyl chloride. The subsequent reaction with triphenylphosphine led to formation of triphenyl(4-pyrazolylmethyl)phosphonium chlorides, and Wittig reaction of the latter with aromatic or heteroaromatic aldehydes yielded 4-[2-aryl(heteryl)ethenyl]pyrazoles.