methyl (Z)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-pyridin-2-ylprop-2-enoate | 1259394-68-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (Z)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-pyridin-2-ylprop-2-enoate
• CAS: 1259394-68-7
• 化学式: C₁₄H₁₈N₂O₄
• 分子量: 278.308
• InChiKey: PRYVFYLUZVGHTC-LUAWRHEFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  77.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吡啶-2-甲醛 、 trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate 在 potassium carbonate 作用下， 反应 7.0h， 以88%的产率得到methyl (Z)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-pyridin-2-ylprop-2-enoate
  参考文献：
  名称：

  Solvent-free synthesis of unsaturated amino esters in a ball-mill

  摘要：

  The ball-milling technique was used under solvent-free conditions to perform a Horner-Wadsworth-Emmons reaction in the presence of a mild carbonate base. Starting from a phosphonate-substituted glycine, this method gave access to Boc-protected unsaturated amino esters in excellent yield and selectivity in many cases. The scope of the reaction was delineated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.069

文献信息

• [EN] HERBICIDALLY ACTIVE 2-HALOGEN-4-ALKYNYL-PHENYL-PYRAZOLIDINE-DIONE OR PYRROLIDINE-DIONE DERIVATIVES<br/>[FR] DÉRIVÉS DE 2-HALOGÉNO-4-ALCYNYLPHÉNYLPYRAZOLIDINEDIONE OU DE PYRROLIDINEDIONE AYANT UNE ACTIVITÉ HERBICIDE
  申请人：SYNGENTA LTD

  公开号：WO2015040114A1

  公开（公告）日：2015-03-26

  The present invention relates to a compound of formula (I), wherein CKE is of sub-formula (A) and/or (B), wherein: R1 is methyl or methoxy; R2 is hydrogen, methyl, ethyl, n-propyl, n-butyl, cyclopropyl, ethynyl, cyano, C1-C3alkoxy, C1-C2fluoroalkoxy, (difluoro)vinyloxy, C1-C2alkoxy-C1-C3alkoxy-, or C1fluoroalkoxy-C1C3alkoxy-; and X is NR4 or CR5R6; wherein R3, R4, R5 and R6 are as defined herein; wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.

  本发明涉及一种化合物，其化学式为（I），其中CKE为亚式结构（A）和/或（B），其中：R1为甲基或甲氧基；R2为氢、甲基、乙基、正丙基、正丁基、环丙基、乙炔基、氰基、C1-C3烷氧基、C1-C2氟烷氧基、（二氟）乙烯氧基、C1-C2烷氧基-C1-C3烷氧基、或C1氟烷氧基-C1C3烷氧基；X为NR4或CR5R6；其中R3、R4、R5和R6如本文所定义；其中该化合物的化学式（I）可选地存在于其农药可接受的盐中。这些化合物适用于用作除草剂。因此，本发明还涉及一种控制杂草，特别是草本单子叶杂草，在有用植物作物中的方法，包括将化合物的化学式（I）或包含这种化合物的除草剂组合物施用于植物或其生长地点。
• Solvent-free synthesis of unsaturated amino esters in a ball-mill
  作者：Alice Baron、Jean Martinez、Frédéric Lamaty

  DOI：10.1016/j.tetlet.2010.09.069

  日期：2010.12

  The ball-milling technique was used under solvent-free conditions to perform a Horner-Wadsworth-Emmons reaction in the presence of a mild carbonate base. Starting from a phosphonate-substituted glycine, this method gave access to Boc-protected unsaturated amino esters in excellent yield and selectivity in many cases. The scope of the reaction was delineated. (C) 2010 Elsevier Ltd. All rights reserved.