2-acetylcyclopentane-1,3-dione | 34785-56-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯基酸
• 英文名称: 2-acetylcyclopentane-1,3-dione
• 英文别名: 2-Acetyl-3-hydroxycyclopent-2-en-1-one
• CAS: 34785-56-3
• 化学式: C₇H₈O₃
• 分子量: 140.139
• InChiKey: RONRCPCLDTZROD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-acetylcyclopentane-1,3-dione 以 氘代氯仿 为溶剂， 生成 2-acetylcyclopentane-1,3-dione
  参考文献：
  名称：

  Borisov, E. V.; Khlebnikova, T. S.; Rubinov, D. B., Russian Journal of Organic Chemistry, 1992, vol. 28, # 6.2, p. 1027 - 1028

  摘要：

  DOI：
• 作为产物：
  描述：

  2-acetylcyclopentane-1,3-dione 以 氘代氯仿 为溶剂， 生成 2-acetylcyclopentane-1,3-dione
  参考文献：
  名称：

  Borisov, E. V.; Khlebnikova, T. S.; Rubinov, D. B., Russian Journal of Organic Chemistry, 1992, vol. 28, # 6.2, p. 1027 - 1028

  摘要：

  DOI：

文献信息

• Treating and/or preventing insulin-resistance related weight gain
  申请人：University of South Florida

  公开号：US10688063B2

  公开（公告）日：2020-06-23

  Provided herein are methods of preventing or reducing weight gain in a subject in need thereof by administering 2-acetylcyclopentane-1,3-dione (ACPD).

  本文提供了通过施用 2-乙酰基环戊烷-1,3-二酮（ACPD）来防止或减少有需要的受试者体重增加的方法。
• Method of treating melanoma using an inhibitor of an atypical protein kinase C
  申请人：UNIVERSITY OF SOUTH FLORIDA

  公开号：US10918650B2

  公开（公告）日：2021-02-16

  The invention pertains to a method of treating melanoma by administering to a subject in need thereof, a composition comprising a therapeutically effective amount of an inhibitor of PKC-ζ and/or PKC-ι. Non-limiting examples of an inhibitor of PKC-ζ and/or PKC-ι include ICA-1 and ACPD. The invention also provides PKC-ζ and/or PKC-ι as biomarkers for identifying a melanoma in a subject as likely to be responsive or non-responsive to a therapy using an inhibitor of PKC-ζ and/or PKC-ι. Accordingly, a method of identifying a subject having a melanoma as being responsive or non-responsive to a melanoma therapy with an inhibitor of PKC-ζ and/or PKC-ι based on the levels and/or activity of PKC-ζ and/or PKC-ι mRNA or protein in the melanoma cells from the subject are also provided.

  本发明涉及一种治疗黑色素瘤的方法，其方法是向有需要的受试者施用一种组合物，该组合物包含治疗有效量的PKC-ζ和/或PKC-ι抑制剂。PKC-ζ和/或PKC-ι抑制剂的非限制性实例包括ICA-1和ACPD。本发明还提供了PKC-ζ和/或PKC-ι作为生物标记物，用于鉴定受试者的黑色素瘤可能对使用PKC-ζ和/或PKC-ι抑制剂的疗法有反应或无反应。相应地，还提供了一种根据受试者黑色素瘤细胞中PKC-ζ和/或PKC-ι mRNA或蛋白质的水平和/或活性，确定受试者的黑色素瘤对使用PKC-ζ和/或PKC-ι抑制剂的黑色素瘤疗法有反应或无反应的方法。
• AXREM A. A.; LAXVICH F. A.; XRIPACH V. A.; KLEBANOVICH I. B.; POZDEEV A. +, XIMIYA GETEROTSIKL. SOEDIN. <KGSS-AQ>, 1976, HO 5, 625-628
  作者：AXREM A. A.、 LAXVICH F. A.、 XRIPACH V. A.、 KLEBANOVICH I. B.、 POZDEEV A. +

  DOI：——

  日期：——
• METHOD OF TREATING OVARIAN CANCER USING A PKC INHIBITOR
  申请人：Acevedo-Duncan Mildred Enid

  公开号：US20150366883A1

  公开（公告）日：2015-12-24

  A method of treating ovarian cancer by administering a PKC inhibitor is presented herein. It was found that administering a PKC inhibitor, such as ACPD or ICA-1, to ovarian cancer cells inhibited cancer cell proliferation.
• TREATING AN ATYPICAL PROTEIN KINASE C ENZYME ABNORMALITY
  申请人：UNIVERSITY OF SOUTH FLORIDA

  公开号：US20160175274A1

  公开（公告）日：2016-06-23

  Provided herein are compounds, compositions, pharmaceutical formulations, methods of treating and methods of using aPKC inhibitors for treating and/or preventing of aPKC abnormalities.

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