4-amino-1-[(1S,3R)-3-(hydroxymethyl)cyclopentyl]pyrimidin-2-one

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: 4-amino-1-[(1S,3R)-3-(hydroxymethyl)cyclopentyl]pyrimidin-2-one
• 化学式: C₁₀H₁₅N₃O₂
• 分子量: 209.24
• InChiKey: FPPFSNOWBUKXRB-SFYZADRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• FUNCTIONAL MOLECULE, FUNCTIONAL MOLECULE SYNTHESIZING AMIDITE AND TARGET SUBSTANCE ANALYSIS METHOD
  申请人：FUJIHARA Tsuyoshi

  公开号：US20090053710A1

  公开（公告）日：2009-02-26

  To provide a functional molecule including a modified nucleotide unit having a substituent introduced to a base thereof, wherein the substituent is removably introduced to the base; a functional molecule synthesizing amidite that has a substituent removably introduced to its base and that is used for the manufacture of the functional molecule; and a target substance analysis method including: preparing a random pool of functional molecules using a functional molecule synthesizing amidite; screening a functional molecule having affinity for a target substance from the random pool; amplifying the functional molecules having affinity for the target substance, wherein the method further comprises, prior to the amplification step, removing a substituent from the functional molecule having affinity for the target substance.

  提供一种功能分子，其中包括具有引入取代基的修饰核苷酸单元，其中取代基可被移除，以及用于制造该功能分子的功能分子合成酰胺；还提供一种目标物分析方法，包括：使用功能分子合成酰胺制备随机池的功能分子；从随机池筛选出具有亲和力的功能分子；扩增具有亲和力的功能分子，其中该方法还包括，在扩增步骤之前，从具有亲和力的功能分子中去除取代基。