3'-hydroxy-4'-methoxycarbonyl-1'-4-bromophenylspiro[indoline-3,5'-pyrroline]-2,2'-dione | 1443222-03-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 3'-hydroxy-4'-methoxycarbonyl-1'-4-bromophenylspiro[indoline-3,5'-pyrroline]-2,2'-dione
• 英文别名: methyl 1'-(4-bromophenyl)-4'-hydroxy-2,5'-dioxospiro[1H-indole-3,2'-pyrrole]-3'-carboxylate
• CAS: 1443222-03-4
• 化学式: C₁₉H₁₃BrN₂O₅
• 分子量: 429.227
• InChiKey: YUTVKEUUGXEWEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  95.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  靛红 、 丁炔二酸二甲酯 、 4-溴苯胺 在 titanium(IV) oxide 、 十六烷基三甲基溴化铵 作用下， 以 水 为溶剂， 反应 18.0h， 以73%的产率得到3'-hydroxy-4'-methoxycarbonyl-1'-4-bromophenylspiro[indoline-3,5'-pyrroline]-2,2'-dione
  参考文献：
  名称：

  Admicellar catalysis in multicomponent synthesis of polysubstituted pyrrolidinones

  摘要：

  A multicomponent green methodology was developed to synthesize 3-hydroxy-2-pyrrolidinones under admicellar catalysis by TiO2 nano-particles at room temperature (30 degrees C). TiO2 nano-particles in aqueous CTAB solution promote the formation of admicelles and the reaction occurs in admicellar environment. The methodology was successfully applied to synthesize a variety of 3-hydroxy-2-pyrrolidinones and 3'-hydroxyspiro-2'-pyrrolidinone derivatives. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.017

文献信息

• Admicellar catalysis in multicomponent synthesis of polysubstituted pyrrolidinones
  作者：Rajib Sarkar、Chhanda Mukhopadhyay

  DOI：10.1016/j.tetlet.2013.05.017

  日期：2013.7

  A multicomponent green methodology was developed to synthesize 3-hydroxy-2-pyrrolidinones under admicellar catalysis by TiO2 nano-particles at room temperature (30 degrees C). TiO2 nano-particles in aqueous CTAB solution promote the formation of admicelles and the reaction occurs in admicellar environment. The methodology was successfully applied to synthesize a variety of 3-hydroxy-2-pyrrolidinones and 3'-hydroxyspiro-2'-pyrrolidinone derivatives. (C) 2013 Elsevier Ltd. All rights reserved.