4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-[1,1'-biphenyl]-3-carboxamide | 337534-90-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-[1,1'-biphenyl]-3-carboxamide
• 英文别名: 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl[1,1'-biphenyl]-3-carboxamide；3-[4-[1-hydroxy-1-(1H-imidazol-5-yl)-2-methylpropyl]phenyl]-N-methylbenzamide
• CAS: 337534-90-4
• 化学式: C₂₁H₂₃N₃O₂
• 分子量: 349.433
• InChiKey: CFCJVXMNOZCNMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  78
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid 在 四(三苯基膦)钯 、 吡啶盐酸盐 、 sodium carbonate 作用下， 以 甲醇 、 乙二醇二甲醚 、 水 为溶剂， 反应 20.0h， 生成 4'-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-[1,1'-biphenyl]-3-carboxamide
  参考文献：
  名称：

  17,20-裂解酶抑制剂。第3部分：作为新型17,20-裂解酶抑制剂的联苯基甲基甲基咪唑衍生物的设计，合成和结构-活性关系

  摘要：

  合成了一系列新颖的联苯甲酰基甲基咪唑衍生物和相关化合物，作为类固醇激素生产中的关键酶17,20-裂合酶的抑制剂，并对其生物学活性进行了评估。为了确定17,20-裂解酶对相关CYP3A4酶的有效和选择性抑制剂，使用哺乳动物CYP2C5酶的X射线晶体学结构开发了人17,20-裂解酶的同源性模型。借助分子建模，对联苯部分进行了优化，得到了乙酰胺衍生物，将其通过HPLC拆分，得到了活性（-）-对映异构体。所获得的活性对映异构体不仅显示出对大鼠和人的17,20-裂合酶均具有有效的抑制作用，且IC 50值分别为14和26 nM，但对CYP3A4抑制17,20-裂解酶的选择性也极好（> 300倍）。此外，单只口服给药后，该活性对映异构体可显着降低猴子模型中的血清睾丸激素和DHEA浓度。活性对映体的不对称合成也通过使用非对映选择性格氏反应的手性中间体进行。

  DOI：

  10.1016/j.bmc.2011.02.009

文献信息

• 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US06518257B1

  公开（公告）日：2003-02-11

  To provide a composition having a steroid C17,20-lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: wherein R is a hydrogen atom or a protecting group, R1 is a lower alkyl group or a cyclic hydrocarbon group, R2 is an aromatic hydrocarbon group optionally having substituents or an aromatic heterocyclic group optionally having substituents, R3 is a hydrocarbon group optionally having substituents, a hydroxyl group optionally having substituents, a thiol group optionally having substituents, an amino group optionally having substituents, an acyl group or a halogen atom, and n is an integer of 0 to 4, and a salt thereof have a steroid C17,20-lyase inhibitory activity, and are useful as an agent for the pophylaxis or treatment of prostatism and tumors such as beast cancer and the like.

  提供一种具有类固醇C17,20-裂解酶抑制活性的化合物，并且作为预防或治疗前列腺增生和乳腺癌等肿瘤的药物。所述化合物的结构式如下：其中R为氢原子或保护基，R1为较低的烷基或环烃基，R2为芳香烃基，可选择地具有取代基，或芳香杂环基，可选择地具有取代基，R3为烃基，可选择地具有取代基，羟基，可选择地具有取代基，硫醇基，可选择地具有取代基，氨基，可选择地具有取代基，酰基或卤原子，n为0到4的整数，以及其盐具有类固醇C17,20-裂解酶抑制活性，并且作为预防或治疗前列腺增生和乳腺癌等肿瘤的药物。
• 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1227086A1

  公开（公告）日：2002-07-31

  [Problem] To provide a composition having a steroid C17,20 lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: wherein R is a hydrogen atom or a protecting group, R1 is a lower alkyl group or a cyclic hydrocarbon group, R2 is an aromatic hydrocarbon group optionally having substituents or an aromatic heterocyclic group optionally having substituents, R3 is a hydrocarbon group optionally having substituents, a hydroxyl group optionally having substituents, a thiol group optionally having substituents, an amino group optionally having substituents, an acyl group or a halogen atom, and n is an integer of 0 to 4, and a salt thereof have a steroid C17,20-lyase inhibitory activity, and are useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer and the like.

  [问题] 提供一种组合物，该组合物具有类固醇 C17,20 裂解酶抑制活性，可作为预防或治疗前列腺炎和乳腺癌等肿瘤的药物。一种由式表示的化合物： 其中 R 是氢原子或保护基，R1 是低级烷基或环状烃基，R2 是任选具有取代基的芳香烃基或任选具有取代基的芳香杂环基，R3 是任选具有取代基的烃基、任选具有取代基的羟基、R3为可选具有取代基的烃基、可选具有取代基的羟基、可选具有取代基的硫醇基、可选具有取代基的氨基、酰基或卤素原子，且 n 为 0 至 4 的整数，这些化合物及其盐具有类固醇 C17,20-lyase 抑制活性，可用作预防或治疗前列腺疾病和乳腺癌等肿瘤的药物。
• US6518257B1
  申请人：——

  公开号：US6518257B1

  公开（公告）日：2003-02-11
• 17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure–activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors
  作者：Tomohiro Kaku、Saori Tsujimoto、Nobuyuki Matsunaga、Toshimasa Tanaka、Takahito Hara、Masuo Yamaoka、Masami Kusaka、Akihiro Tasaka

  DOI：10.1016/j.bmc.2011.02.009

  日期：2011.4

  A novel series of biphenylylmethylimidazole derivatives and related compounds were synthesized as inhibitors of 17,20-lyase, a key enzyme in the production of steroid hormones, and their biological activities were evaluated. In an attempt to identify potent and selective inhibitors of 17,20-lyase over the related CYP3A4 enzyme, a homology model for human 17,20-lyase was developed using the X-ray crystallographic

  合成了一系列新颖的联苯甲酰基甲基咪唑衍生物和相关化合物，作为类固醇激素生产中的关键酶17,20-裂合酶的抑制剂，并对其生物学活性进行了评估。为了确定17,20-裂解酶对相关CYP3A4酶的有效和选择性抑制剂，使用哺乳动物CYP2C5酶的X射线晶体学结构开发了人17,20-裂解酶的同源性模型。借助分子建模，对联苯部分进行了优化，得到了乙酰胺衍生物，将其通过HPLC拆分，得到了活性（-）-对映异构体。所获得的活性对映异构体不仅显示出对大鼠和人的17,20-裂合酶均具有有效的抑制作用，且IC 50值分别为14和26 nM，但对CYP3A4抑制17,20-裂解酶的选择性也极好（> 300倍）。此外，单只口服给药后，该活性对映异构体可显着降低猴子模型中的血清睾丸激素和DHEA浓度。活性对映体的不对称合成也通过使用非对映选择性格氏反应的手性中间体进行。