N-phenyl-5-trichloromethyl-1,2,4-oxadiazolyl-3-carboxamide | 519186-83-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-5-trichloromethyl-1,2,4-oxadiazolyl-3-carboxamide
• 英文别名: 1,2,4-Oxadiazole-3-carboxamide, 5-trichloromethyl-N-phenyl-；N-phenyl-5-(trichloromethyl)-1,2,4-oxadiazole-3-carboxamide
• CAS: 519186-83-5
• 化学式: C₁₀H₆Cl₃N₃O₂
• 分子量: 306.536
• InChiKey: FRWJOFIQVLBYLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  68
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  偏二甲肼 、 N-phenyl-5-trichloromethyl-1,2,4-oxadiazolyl-3-carboxamide 以 甲醇 为溶剂， 反应 12.0h， 以75%的产率得到N-phenyl-5-(2,2-dimethylhydrazonomethyl)-1,2,4-oxadiazolyl-3-carboxamide
  参考文献：
  名称：

  摘要：

  A convenient method for the synthesis of 3-carbamoyl-1,2,4-oxadiazoles from carbamoyl-amidoximes and chlorides or anhydrides of haloacetic acids was developed. The reactions of 3-carbamoyl-5-trichloromethyl-1,2,4-oxadiazoles with amines and N,N-dimethylhydrazine were studied.

  DOI：

  10.1023/a:1021348401329
• 作为产物：
  描述：

  三氯乙酰氯 、 N(1)-phenyl-2-amino-2-hydroxyiminoacetamide 在 sodium carbonate 作用下， 以 various solvent(s) 为溶剂， 反应 1.5h， 以70%的产率得到N-phenyl-5-trichloromethyl-1,2,4-oxadiazolyl-3-carboxamide
  参考文献：
  名称：

  摘要：

  A convenient method for the synthesis of 3-carbamoyl-1,2,4-oxadiazoles from carbamoyl-amidoximes and chlorides or anhydrides of haloacetic acids was developed. The reactions of 3-carbamoyl-5-trichloromethyl-1,2,4-oxadiazoles with amines and N,N-dimethylhydrazine were studied.

  DOI：

  10.1023/a:1021348401329

文献信息

• ——
  作者：V. N. Yarovenko、S. A. Kosarev、I. V. Zavarzin、M. M. Krayushkin

  DOI：10.1023/a:1021348401329

  日期：——

  A convenient method for the synthesis of 3-carbamoyl-1,2,4-oxadiazoles from carbamoyl-amidoximes and chlorides or anhydrides of haloacetic acids was developed. The reactions of 3-carbamoyl-5-trichloromethyl-1,2,4-oxadiazoles with amines and N,N-dimethylhydrazine were studied.