7-(beta-Chloroallyloxy)-4-methylcoumarin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-(beta-Chloroallyloxy)-4-methylcoumarin
• 英文别名: 7-(2-chloroprop-2-enoxy)-4-methylchromen-2-one
• 化学式: C₁₃H₁₁ClO₃
• 分子量: 250.68
• InChiKey: RWSOGXRLIXDZFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-(beta-Chloroallyloxy)-4-methylcoumarin 、 丁酸酐 、 氯仿 在 氩 、 水 、 碳酸氢钠 、 magnesium sulfate 、 乙醇 作用下， 以 1,4-二异丙基苯 为溶剂， 反应 18.0h， 以8-(β-chloroallyl)-7-butyroxy-4-methylcoumarin (BCAMC,15) were obtained的产率得到8-(beta-Chloroallyl)-7-butyroxy-4-methylcoumarin
  参考文献：
  名称：

  Method for photoactivation

  摘要：

  一种激活光敏化合物的方法，通过在选定温度下支撑含有光敏化合物的样品容器，并在保持样品容器与照射源的固定关系的同时照射样品容器，以便均匀照射化合物。

  公开号：

  US05503721A1

文献信息

• Device and method for photoactivation
  申请人：Cerus Corporation

  公开号：US20030170141A1

  公开（公告）日：2003-09-11

  A device comprising a light source, a sample support and a temperature control compartment. The sample support is positioned to support multiple sample vessels for irradiation by the light source. The temperature control compartment maintains the temperature of the sample vessels within a desired range. The light source, sample support and temperature control compartment are all contained within an opaque housing.

  一个装置包括一个光源、一个样品支架和一个温度控制隔室。样品支架被定位以支持多个样品容器，以便被光源照射。温度控制隔室保持样品容器的温度在所需范围内。光源、样品支架和温度控制隔室都包含在不透明的外壳内。
• Methods for rendering amplified nucleic acid subsequently unamplifiable
  申请人：——

  公开号：US05221608A1

  公开（公告）日：1993-06-22

  Method for treating nucleic acid that is to be amplified such that the nucleic acid is, after amplification, subsequently unamplifiable. Nucleic acid amplification is performed in a reaction containing means in the presence of an isopsoralen. The reaction is thereafter irradiated to render the amplified nucleic acid substantially unamplifiable.

  一种用于处理要被扩增的核酸的方法，使得经过扩增后的核酸随后不可再被扩增。在存在异噻索烯的情况下进行核酸扩增反应。然后对反应进行辐照，使扩增的核酸基本上不可再被扩增。
• Activation compounds and methods of synthesis of activation compounds
  申请人：——

  公开号：US05139940A1

  公开（公告）日：1992-08-18

  The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.

  本发明涉及含有多种取代基的异毛光素化合物组成物，这些取代基允许它们与核酸聚合物结合。激活这些结合的反应条件导致异毛光素与核酸聚合物之间的共价交联。所得到的复合物不能成为用于模板定向的酶促合成互补核酸聚合物的模板。除了异毛光素组成物之外，本发明还包括它们的合成、核酸复合物的生产和检测以及使用异毛光素的上述抑制方法。
• A device for nucleic acid sterilization
  申请人：ISAACS, Stephen T.

  公开号：EP0890363A2

  公开（公告）日：1999-01-13

  The invention relates to a device, comprising means for providing electromagnetic radiation (101-106; 201-206; 301-308); means for supporting a sample (109;315) in a fixed relationship with said radiation providing means during irradiation; a housing (100;200;300) for containing said radiation providing means; and means for maintaining the temperature of said sample within a desired temperature range during said irradiation comprising a chamber (107;207;309) positioned interior to said housing and in a fixed relationship to said radiation providing means.

  本发明涉及一种设备，包括用于提供电磁辐射的装置（101-106；201-206；301-308）；用于在辐照期间支撑与所述辐射提供装置保持固定关系的样品（109；315）的装置；用于容纳所述辐射提供装置的外壳（100；200；300）；以及用于在所述辐照期间将所述样品的温度保持在所需温度范围内的装置，该装置包括一个位于所述外壳内部并与所述辐射提供装置保持固定关系的腔室（107；207；309）。
• ACTIVATION COMPOUNDS AND METHODS FOR NUCLEIC ACID STERILIZATION
  申请人：ISAACS, Stephen T.

  公开号：EP0497921A1

  公开（公告）日：1992-08-12