7-methoxy-4-[3-(4-methoxyphenyl)prop-2-enoyl]chromen-2-one | 1253932-09-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-methoxy-4-[3-(4-methoxyphenyl)prop-2-enoyl]chromen-2-one
• CAS: 1253932-09-0
• 化学式: C₂₀H₁₆O₅
• 分子量: 336.344
• InChiKey: ORITUEDLCIYZLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.71
• 重原子数：
  25.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  65.74
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  4-甲氧基苯甲醛 、 4-acetyl-7-methoxy-2H-chromen-2-one 在 四氢吡咯 作用下， 以 乙醇 为溶剂， 生成 7-methoxy-4-[3-(4-methoxyphenyl)prop-2-enoyl]chromen-2-one
  参考文献：
  名称：

  Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines

  摘要：

  Histone deacetylases (HDACs) are well-established, promising targets for anticancer therapy due to their critical role in cancer development. Accordingly, an increasing number of HDAC inhibitors displaying cytotoxic effects against cancer cells have been reported. Among them, a large panel of chemical structures was described including coumarin-containing molecules. In this study, we described synthesis and biological activity of new coumarin-based derivatives as HDAC inhibitors. Among eight derivatives, three compounds showed HDAC inhibitory activities and antitumor activities against leukemia cell lines without affecting the viability of peripheral blood mononuclear cells from healthy donors.

  DOI：

  10.1016/j.bmcl.2014.06.067

文献信息

• Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases
  作者：Sergio Valente、Emilie Bana、Elodie Viry、Denyse Bagrel、Gilbert Kirsch

  DOI：10.1016/j.bmcl.2010.07.130

  日期：2010.10

  The cell division cycle 25 (Cdc25) family of proteins are dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. Overexpression of Cdc25 proteins has been reported in a wide variety of cancers; their inhibition may thus represent a novel approach for the development of anticancer therapeutics. Herein we report new coumarin-based scaffolds endowed with a selective inhibition against Cdc25A and Cdc25C, being 6a and 6d the most efficient inhibitors and worthy of further investigation as anticancer agents. (C) 2010 Elsevier Ltd. All rights reserved.