2,3-Dichloro-N,N-dimethylpropanamide | 105552-94-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,3-Dichloro-N,N-dimethylpropanamide
• CAS: 105552-94-1
• 化学式: C₅H₉Cl₂NO
• 分子量: 170.03
• InChiKey: PBOXFJRADXLVGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same
  申请人：Klein Peter J.

  公开号：US20050049262A1

  公开（公告）日：2005-03-03

  Novel heterocyclic compounds having a six membered ring structure fused to a five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by lnterleukin-12 (“IL-12”) intracellular signaling, such as, for example, Th1 cell-mediated disorders. The therapeutic compounds, pharmaceutically acceptable derivatives (e.g., resolved enantiomers, diastereomers, tautomers, salts and solvates thereof) or prodrugs thereof, have the following general formula: Each X, Y and Z are independently selected from a member of the group consisting of C(R 3 ), N, N(R 3 ) and S. Each R 1 , R 2 and R 3 is substituted or unsubstituted and is independently selected from a member of the group consisting of hydrogen, halo, oxo, C (1-20) alkyl, C (1-20) hydroxyalkyl, C (1-20) thioalkyl, C (1-20) alkylamino, C (1-20) alkylaminoalkyl, C (1-20) aminoalkyl, C (1-20) aminoalkoxyalkenyl, C (1-20) aminoalkoxyalkynyl, C (1-20) diaminoalkyl, C (1-20) triaminoalkyl, C (1-20) tetraaminoalkyl, C (5-15) aminotrialkoxyamino, C (1-20) alkylamido, C (1-20) alkylamidoalkyl, C (1-20) amidoalkyl, C (1-20) acetamidoalkyl, C (1-20) alkenyl, C (1-20) alkynyl, C (3-8) alkoxyl, C (1-11) alkoxyalkyl, and C (1-20) dialkoxyalkyl.

  具有六元环结构融合到五元环结构的新型杂环化合物被发现可用于治疗和预防与受白细胞介素-12（“IL-12”）细胞内信号传导影响的疾病症状或表现，例如Th1细胞介导的疾病。治疗化合物，药学上可接受的衍生物（例如，解析对映体，非对映体，互变异构体，其盐和溶剂化物）或其前药，具有以下通用公式： 每个X，Y和Z独立地从C（R3），N，N（R3）和S组成的组中选择。每个R1，R2和R3被取代或未取代，并且独立地从氢，卤素，氧代，C（1-20）烷基，C（1-20）羟基烷基，C（1-20）硫代烷基，C（1-20）烷基氨基，C（1-20）烷基氨基烷基，C（1-20）氨基烷基，C（1-20）氨基烷氧基烯基，C（1-20）氨基烷氧基炔基，C（1-20）二氨基烷基，C（1-20）三氨基烷基，C（1-20）四氨基烷基，C（5-15）氨基三烷氧基氨基，C（1-20）烷基酰胺基，C（1-20）烷基酰胺基烷基，C（1-20）酰胺基烷基，C（1-20）乙酰胺基烷基，C（1-20）烯基，C（1-20）炔基，C（3-8）烷氧基，C（1-11）烷氧基烷基和C（1-20）二烷氧基烷基中独立选择。
• Purification of aziridine-2-carboxylic acid salts
  申请人：RESEARCH ASSOCIATION FOR UTILIZATION OF LIGHT OIL

  公开号：EP0191462A1

  公开（公告）日：1986-08-20

  Alkaline earth metal salts of aziridine-2-carboxylic acid, typically Ca salt, are produced by a reaction of a 2,3-diha- iopropionic acid derivative or an a-haloacrylic acid derivative with an aqueous ammonia in the presence of an alkaline earth metal hydroxide, typically Ca(OH)2. Salts of aziridine-2-carboxylic acid are recovered from such a reaction product as referred to above by a liquid chromatographic technique in which a weak or weakened cation exchanger is utilized.

  氮丙啶-2-羧酸的碱土金属盐，通常为 Ca 盐，是由 2,3-二哈-碘丙酸衍生物或 a-卤丙烯酸衍生物与水氨在碱土金属氢氧化物（通常为 Ca(OH)2）存在下反应生成的。
• XANTHINE DERIVATIVES AND ANALOGS AS CELL SIGNALLING INHIBITORS
  申请人：CELL THERAPEUTICS, INC.

  公开号：EP1171442B1

  公开（公告）日：2005-12-07
• US4935527A
  申请人：——

  公开号：US4935527A

  公开（公告）日：1990-06-19
• US6878715B1
  申请人：——

  公开号：US6878715B1

  公开（公告）日：2005-04-12