N-benzyl-6-[(2-fluorophenyl)methyl]-1-propan-2-ylbenzimidazol-4-amine | 1228929-70-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-benzyl-6-[(2-fluorophenyl)methyl]-1-propan-2-ylbenzimidazol-4-amine
• CAS: 1228929-70-1
• 化学式: C₂₄H₂₄FN₃
• 分子量: 373.473
• InChiKey: DJLQVCDKPINDFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  29.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  、 苯甲醛 在 三乙酰氧基硼氢化钠 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 12.0h， 生成 N-benzyl-6-[(2-fluorophenyl)methyl]-1-propan-2-ylbenzimidazol-4-amine
  参考文献：
  名称：

  Identification of benzimidazole-based inhibitors of the mitogen activated kinase-5 signaling pathway

  摘要：

  The MEK-signaling pathways are complex but critical signaling cascades that correlate an extracellular signaling event with internal cell processes. To date at least seven MEK isozymes have been identified. MEK5, in particular, is upregulated in multiple forms of tumors. Analysis of the EGF-induced MEK5 signaling cascade in cultured HEK cells has identified compounds that can inhibit MEK5 phosphorylation of ERK5; observed biological activity is dependent on chemical variation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.033

文献信息

• Identification of benzimidazole-based inhibitors of the mitogen activated kinase-5 signaling pathway
  作者：Patrick T. Flaherty、Ishveen Chopra、Prashi Jain、Shuyan Yi、Erika Allen、Jane Cavanaugh

  DOI：10.1016/j.bmcl.2010.03.033

  日期：2010.5

  The MEK-signaling pathways are complex but critical signaling cascades that correlate an extracellular signaling event with internal cell processes. To date at least seven MEK isozymes have been identified. MEK5, in particular, is upregulated in multiple forms of tumors. Analysis of the EGF-induced MEK5 signaling cascade in cultured HEK cells has identified compounds that can inhibit MEK5 phosphorylation of ERK5; observed biological activity is dependent on chemical variation. (C) 2010 Elsevier Ltd. All rights reserved.