(S)-5-methoxymethyl-2-methyl-Δ¹-pyrroline | 360782-59-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: (S)-5-methoxymethyl-2-methyl-Δ¹-pyrroline
• 英文别名: (2S)-2-(methoxymethyl)-5-methyl-3,4-dihydro-2H-pyrrole
• CAS: 360782-59-8
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: NIFNACRFZORBMU-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲基溴化镁 、 (S)-5-methoxymethyl-2-methyl-Δ¹-pyrroline 在 cerium(III) chloride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 4.5h， 以15%的产率得到(S)-5,5-dimethyl-2-methoxymethyl-pyrrolidine
  参考文献：
  名称：

  SYNTHESIS OF A NEW CHIRAL AMINE:(S)-5,5-DIMETHYL-2-METHOXYMETHYL-PYRROLIDINE

  摘要：

  The title compound, a potential 'quat' auxiliary,was prepared from (S)-glutamic acid derivatives like (S)-N-Benzyl-5-methoxymethyl-2pyrrolidinone 1. Other routes starting from (S)-pyroglutamic acid in an attempt to bypass N-Aryl compounds like 1 were also tested, but. have not rendered the expected results yet.

  DOI：

  10.1081/scc-100103258
• 作为产物：
  描述：

  (S)-5-(methoxymethyl)-1-(phenylmethyl)-2-pyrrolidinone 在 4-二甲氨基吡啶 、 氨 、 lithium 、 三氟乙酸 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 30.0h， 生成 (S)-5-methoxymethyl-2-methyl-Δ¹-pyrroline
  参考文献：
  名称：

  SYNTHESIS OF A NEW CHIRAL AMINE:(S)-5,5-DIMETHYL-2-METHOXYMETHYL-PYRROLIDINE

  摘要：

  The title compound, a potential 'quat' auxiliary,was prepared from (S)-glutamic acid derivatives like (S)-N-Benzyl-5-methoxymethyl-2pyrrolidinone 1. Other routes starting from (S)-pyroglutamic acid in an attempt to bypass N-Aryl compounds like 1 were also tested, but. have not rendered the expected results yet.

  DOI：

  10.1081/scc-100103258

文献信息

• SYNTHESIS OF A NEW CHIRAL AMINE:(S)-5,5-DIMETHYL-2-METHOXYMETHYL-PYRROLIDINE
  作者：Leonardo J. Breña-Valle、Raymundo Cruz-Almanza、F. Oscar Guadarrama-Morales

  DOI：10.1081/scc-100103258

  日期：2001.1

  The title compound, a potential 'quat' auxiliary,was prepared from (S)-glutamic acid derivatives like (S)-N-Benzyl-5-methoxymethyl-2pyrrolidinone 1. Other routes starting from (S)-pyroglutamic acid in an attempt to bypass N-Aryl compounds like 1 were also tested, but. have not rendered the expected results yet.