2-hydroxy-2-methyl-octadecanoic acid | 109938-03-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-hydroxy-2-methyl-octadecanoic acid
• 英文别名: 2-Hydroxy-2-methyl-octadecansaeure；2-Hydroxy-2-methyloctadecanoic acid
• CAS: 109938-03-6
• 化学式: C₁₉H₃₈O₃
• 分子量: 314.509
• InChiKey: AVGLYNCSDWUUMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  22
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙酮酸乙酯 、 1-hexadecylmagnesium bromide 在 乙醚 作用下， 生成 2-hydroxy-2-methyl-octadecanoic acid
  参考文献：
  名称：

  Baykut, Istanbul Universitesi Fen Fakultesi Mecmuasi, Seri A: Matematik-Fizik-Kimya, 1952, vol. 17, p. 178,180

  摘要：

  DOI：

文献信息

• Additives and products including oligoesters
  申请人：——

  公开号：US20030199593A1

  公开（公告）日：2003-10-23

  The present invention relates to oligoesters and their use or the creation of additives. Oligoester containing additives and/or oligoesters themselves may be used for formulating pharmaceutical preparations, cosmetics or personal care products such as shampoos and conditioners. These oligoesters are particularly useful for the creation of multi-purpose additives that can impart conditioning, long substantivity and/or UV protection. Individual oligoesters and oligoester mixtures are described.

  本发明涉及寡酯及其用途或添加剂的制备。含有寡酯的添加剂和/或寡酯本身可用于配制药物制剂、化妆品或个人护理产品，如洗发水和护发素。这些寡酯对于制备能够赋予调理、长效性和/或紫外线保护的多功能添加剂特别有用。描述了单独的寡酯和寡酯混合物。
• Novel Derivatives of Cyclic Compound And The Use Thereof
  申请人：Cho Hyun Chul

  公开号：US20100022461A1

  公开（公告）日：2010-01-28

  Disclosed is tonovel cyclic derivatives having potent inhibiting effect on melanin formation and skin hyper-pigmentation activity with no adverse response to skin. They can be used as the therapeutics for treating and preventing the skin disease caused by over-reproduced melanin.

  本发明揭示了一种新型的环状衍生物，具有对黑色素形成和皮肤过度色素沉着活性具有强效抑制作用，并且对皮肤没有不良反应。它们可以用作治疗和预防由于黑色素过度产生引起的皮肤疾病的治疗药物。
• Imidazoline quats
  申请人：Croda, Inc.

  公开号：US20040220062A1

  公开（公告）日：2004-11-04

  Mixture of dialkyl imidazoline quats with specified substitution content are provided. In one embodiment, at least a portion of the mixture includes at least one dialkyl imidazoline quat having at least one C 16 -C 30 alkyl group; the C 16-30 substitution content of the mixture being from about 10% to about 95% with respect to C 10+ reference substitution range. Methods of making imidazoline quats and quat mixtures, personal care and cosmetic products and formulations that contain the imidazoline quats and quat mixtures, methods of making such personal care and cosmetic products and formulations, and methods of using the such imidazoline quats, quat mixtures, and personal care and cosmetic products and formulations are also provided. Various embodiments are disclosed.

  提供具有指定取代含量的二烷基咪唑啉季铵盐混合物。在一个实施例中，至少部分混合物包括至少一种具有至少一个C16-C30烷基基团的二烷基咪唑啉季铵盐；混合物的C16-C30取代含量相对于C10+参考取代范围约为10%至95%。还提供制备咪唑啉季铵盐和季铵盐混合物的方法，包含咪唑啉季铵盐和季铵盐混合物的个人护理和化妆品产品和配方，制备这种个人护理和化妆品产品和配方的方法，以及使用这种咪唑啉季铵盐、季铵盐混合物、个人护理和化妆品产品和配方的方法。还披露了各种实施例。
• Compositions containing esters of aromatic alkoxylated alcohols and fatty carboxylic acids
  申请人：——

  公开号：US20030161792A1

  公开（公告）日：2003-08-28

  A personal care or cosmetic product composition that includes from about 0.1% to about 99% of at least one ester of alkoxylated aromatic alcohol and fatty carboxylic acid, and from about 0.1% to 60% of at least one functional ingredient is provided. The functional ingredients in the composition may include active ingredients and additional ingredients. Especially suitable active ingredients are sunscreen active ingredients and antiperspirant active ingredients. Preferred compositions are sunscreen product formulations and antiperspirant products. In one preferred embodiment, the composition further includes at least one cyclomethicone compound present in the amount of from about 1% to 99% by weight of the composition. A method of improving the protection of human or animal skin or hair from radiation and a method of improving the protection of human or animal skin or hair from perspiration are also provided.

  提供一种个人护理或化妆品组合物，包括约0.1%至约99%的至少一种烷氧基芳香醇和脂肪羧酸酯，以及约0.1%至60%的至少一种功能性成分。组合物中的功能性成分可能包括活性成分和额外成分。特别适用的活性成分包括防晒活性成分和止汗活性成分。首选的组合物是防晒产品配方和止汗产品。在一个首选实施例中，该组合物还包括至少一种环硅烷化合物，其占组合物重量的约1%至99%。还提供了一种改善人类或动物皮肤或毛发免受辐射的保护的方法，以及一种改善人类或动物皮肤或毛发免受汗水侵害的方法。
• Esters of aromatic alkoxylated alcohols and fatty carboxylic acids
  申请人：——

  公开号：US20030181744A1

  公开（公告）日：2003-09-25

  Esters of alkoxylated aromatic alcohol and fatty carboxylic acid are provided. The esters are especially suitable as additives for personal care and cosmetic products. The preferred esters having an aromatic nucleus, an alkoxy spacer, an ester carboxylic group, and a fatty alkyl group, in which the aromatic nucleus and the oxygen atom of the ester carboxylic group are connected to the alkoxy spacer, and the fatty alkyl group is attached to the carbon atom of the ester carboxylic group, are also provided. Certain of the esters of alkoxylated aromatic alcohol and fatty carboxylic acid having certain skin spread factor or viscosity are also provided.

  提供了烷氧基化芳香醇和脂肪羧酸的酯。这些酯特别适用于个人护理和化妆品产品的添加剂。优选酯具有芳香核、烷氧间隔、酯羧基和脂肪烷基，其中芳香核和酯羧基的氧原子连接到烷氧间隔，脂肪烷基附着在酯羧基的碳原子上。还提供了具有特定皮肤扩散因子或粘度的某些烷氧基化芳香醇和脂肪羧酸的酯。