4-methylpyroglutamic acid | 64481-08-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-methylpyroglutamic acid
• 英文别名: 4-Methyl-5-oxo-L-proline；(2S)-4-methyl-5-oxopyrrolidine-2-carboxylic acid
• CAS: 64481-08-9
• 化学式: C₆H₉NO₃
• 分子量: 143.142
• InChiKey: XORPMPMQTVXEDJ-BKLSDQPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-formylaminopent-4-enoic acid 以66%的产率得到4-methylpyroglutamic acid
  参考文献：
  名称：

  固体载体上硫醇介导的异氰酸酯的自由基环化

  摘要：

  从市售的Wang和HMBA-AM树脂合成了三种新型的聚合物负载的异氰化物，并使它们在自由基条件下与2-巯基乙醇和乙硫醇反应，以高收率得到相应的吡咯烷或焦谷氨酸衍生物。

  DOI：

  10.1016/j.tetlet.2004.09.078

文献信息

• Histidyl peptide derivatives
  申请人：Japan Tobacco Inc.

  公开号：US05151497A1

  公开（公告）日：1992-09-29

  Novel peptide derivatives of the following formula ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof. Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.

  以下是中文翻译：新型肽衍生物的化学式如下##STR1##其中每个符号如规范中定义的，其药用可接受的酸盐和类似化合物。由于本发明的衍生物及其药用可接受的酸盐具有更强的对中枢神经系统的作用（如对抗低体温的作用、促进运动的作用、刺激反射的作用），因此它们可用作治疗中枢神经系统疾病的药物，如意识障碍、抑郁症、健忘症等，与精神分裂症、忧郁症、老年性痴呆、脑血管疾病后遗症、头部创伤、癫痫和脊髓小脑变性有关。
• BENZIMIDAZOLE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
  申请人：Henderson James A.

  公开号：US20110172238A1

  公开（公告）日：2011-07-14

  Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R 1 , R 1 ′, R 2 , R 2 ′, R 3 , R 3 ′, R 5 , R 5 ′, R 6 , m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.

  公式I所代表的化合物，或其药学上可接受的盐和溶剂化物，其中A、B、B'、X、Y、R1、R1'、R2、R2'、R3、R3'、R5、R5'、R6、m、n或p的定义如本文所述，可用于治疗黄病毒科病毒感染。
• Novel peptide derivatives and their pharmaceutical use
  申请人：JAPAN TOBACCO INC.

  公开号：EP0384380A2

  公开（公告）日：1990-08-29

  Peptide derivatives of the following general formula wherein R1 and R2 are the same or different and respectively mean a hydrogen atom or a C1 -5 alkyl group, R3 and R4 are the same or different and respectively mean a hydrogen atom or a C1 -5 alkyl or phenyl, or R3 and R4 combinedly mean a C2-7 alkylene group, Rs and R6 are the same or different and respectively mean a hydrogen atom or a C1-5 alkyl group, X means -NH-, -O- or -CH2-, Y means -CH2- or -S-, and m and n respectively mean 0 or 1, provided that when X is -NH- or -O-, m is 1 and all of R1, R2, R3 and R4 do not mean a hydrogen atom at the same time; acid addition salts thereof; and pharmaceutical use thereof. Since the compounds and their acid addition salts of the present invention possess more potent actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, spinal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.

  通式如下的多肽衍生物 其中 R1 和 R2 相同或不同，分别表示氢原子或 C1-5 烷基，R3 和 R4 相同或不同，分别表示氢原子或 C1-5 烷基或苯基，或 R3 和 R4 合起来表示 C2-7 亚烷基、Rs和R6相同或不同，分别表示氢原子或C1-5烷基，X表示-NH-、-O-或-CH2-，Y表示-CH2-或-S-，m和n分别表示0或1，但当X为-NH-或-O-时，m为1，且所有R1、R2、R3和R4不同时表示氢原子；其酸加成盐；及其医药用途。 由于本发明的化合物及其酸加成盐对中枢神经系统具有更强的作用（例如对低体温的拮抗作用、运动刺激作用、脊髓反射刺激作用），因此它们可用作治疗中枢神经疾病的药物，如与精神分裂症、忧郁症、老年痴呆症、脑血管疾病后遗症、头部创伤、癫痫和脊髓小脑变性有关的意识障碍、抑郁、失眠等。
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.
• US4177346A
  申请人：——

  公开号：US4177346A

  公开（公告）日：1979-12-04