(2-Methoxyl-1-methylethyl) acetamide | 127727-20-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2-Methoxyl-1-methylethyl) acetamide
• 英文别名: N-(1-methoxypropan-2-yl)acetamide
• CAS: 127727-20-2
• 化学式: C₆H₁₃NO₂
• mdl: MFCD02862110
• 分子量: 131.175
• InChiKey: DEMOIIRMYCGHMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙酸酐 、 2-氨基-1-甲氧基丙烷 在 4-二甲氨基吡啶 作用下， 反应 2.0h， 生成 (2-Methoxyl-1-methylethyl) acetamide
  参考文献：
  名称：

  对映体互补ω-转氨酶催化胺的酶解消旋

  摘要：

  通过使用一对立体互补的PLP依赖性ω-转氨酶，开发了伯α-手性胺生物催化消旋的策略。胺对映异构体的相互转化是通过前手性酮中间体的可逆转氨作用进行的，该中间体是由一对立体互补的ω-转氨酶或具有低立体选择性的单一酶催化的。为了调节系统，非手性氨基受体的类型和浓度被证明是至关重要的。最后，外消旋可通过两种不同胺的交叉转氨来实现，而无需外部氨基受体。在温和的反应条件下，可以将几种在工业上和工业上很重要的胺酶消旋化。

  DOI：

  10.1002/chem.201001602

文献信息

• [EN] SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS<br/>[FR] ANALOGUES D'URÉE PONTÉS SUBSTITUÉS EN TANT QUE MODULATEURS DE SIRTUINE
  申请人：GLAXOSMITHKLINE IP NO 2 LTD

  公开号：WO2016079709A1

  公开（公告）日：2016-05-26

  The present invention relates to novel substituted bridged urea analog compounds of Formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as Sirtuin Modulators useful for increasing lifespan of a cell, and for use in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.

  本发明涉及一种新型的取代桥式脲类似物化合物，其化学式为（I）或其药学上可接受的盐，相应的药物组合物，制备这种化合物的方法以及单独使用或与其他治疗剂联合使用的这些化合物作为Sirtuin调节剂，可用于增加细胞寿命，并用于治疗和/或预防各种疾病和紊乱，包括但不限于与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症和/或潮红有关的疾病或紊乱，以及那些会受益于增加线粒体活性的疾病或紊乱。
• COMPOUND OR ITS TAUTOMER, METAL COMPLEX COMPOUND, COLORED PHOTOSENSITIVE CURING COMPOSITION, COLOR FILTER, AND PRODUCTION
  申请人：MIZUKAWA Yuki

  公开号：US20120238752A1

  公开（公告）日：2012-09-20

  Provided is a colored photosensitive curing composition useful for color filters in primary colors, including blue, green, and red, having a high molar absorption coefficient and allowing a reduction in film thickness and superior color purity and fastness. A colored photosensitive curing composition, comprising, as its colorant, a dipyrromethene-based metal complex compound obtained from a metal or metal compound and a dipyrromethene-based compound represented by the following Formula (I): wherein in Formula (I), R 1 to R 6 each independently represent a hydrogen atom or a substituent group; and R 7 represents a hydrogen or halogen atom, or an alkyl, aryl or heterocyclic group.

  提供的是一种有用于原色彩色滤光片的彩色光敏固化组合物，包括蓝色、绿色和红色，具有高摩尔吸收系数，可减少薄膜厚度，具有优越的颜色纯度和牢固度。 一种彩色光敏固化组合物，包括作为其着色剂的从金属或金属化合物获得的基于二吡咯甲烷的金属配合物化合物和由以下式（I）表示的基于二吡咯甲烷的化合物，其中在式（I）中，R1至R6各自独立地表示氢原子或取代基；R7表示氢或卤素原子，或烷基、芳基或杂环基。
• [EN] PESTICIDAL COMPOUNDS<br/>[FR] COMPOSÉS PESTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2016012333A1

  公开（公告）日：2016-01-28

  A method of combating and controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I), wherein R1 is R4, YR5 or ZR6; Y is CO or C=S; Z is S, S(O), SO2 or PO2; and A is an optionally substituted phenyl or an optionally substituted heteroaromatic ring, wherein R1 to R6 are defined organic groups; new compounds are also provided.

  一种用于对抗和控制昆虫、螨虫、线虫或软体动物的方法，包括向害虫、害虫栖息地或易受害虫攻击的植物施加化学式(I)中的一种化合物的杀虫、杀螨、杀线虫或杀软体动物有效量，其中R1为R4、YR5或ZR6；Y为CO或C=S；Z为S、S(O)、SO2或PO2；A为一个可选择取代的苯基或可选择取代的杂环，其中R1至R6为定义的有机基团；还提供了新的化合物。
• Kinase Inhibitors
  申请人：Xiao Xiao-Yi

  公开号：US20080200485A1

  公开（公告）日：2008-08-21

  Disclosed are protein kinase inhibitors, compositions comprising such inhibitors, and methods of use, thereof. More particularly, disclosed are inhibitors of Aurora-2 (Aurora-A) protein kinase. Also disclosed are methods of treating diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.

  本发明涉及蛋白激酶抑制剂、包含该类抑制剂的组合物以及其使用方法。更具体地，本发明涉及Aurora-2（Aurora-A）蛋白激酶的抑制剂。还公开了治疗与蛋白激酶相关的疾病，特别是与Aurora-2相关的疾病，例如癌症的方法。
• PROCESS FOR PREPARING CARBOXYLIC ACID AMIDES USEFUL IN THE TREATMENT OF MUSCULAR DISORDERS
  申请人：Selwood David

  公开号：US20120101301A1

  公开（公告）日：2012-04-26

  The present invention relates to a process for preparing a compound of formula wherein: R 2 is cycloalkyl or alkyl, each of which may be optionally substituted; Y is —CONR 3 R 4 , —CN or CO 2 R 5 ; R 3 , R 4 and R 5 are each independently H or alkyl; n is 1 to 6; wherein said process comprising the steps of: (i) treating a compound of formula (IV), where R 1 is alkyl, with a compound of formula (V) and forming a compound of formula (IIIb); (ii) treating said compound of formula (IIIb) with a compound of formula (I1) to form a compound of formula (I).

  本发明涉及一种制备以下式子化合物的方法：其中：R2是环烷基或烷基，每个基团都可以选择性地被取代；Y是—CONR3R4，—CN或CO2R5；R3、R4和R5分别是H或烷基；n为1到6；其中所述方法包括以下步骤：(i)用式子(IV)化合物（其中R1是烷基）处理式子(V)化合物，形成式子(IIIb)化合物；(ii)用式子(I1)化合物处理所述式子(IIIb)化合物，形成式子(I)化合物。