4,4'-(1,6-hexanediyldiimino)bis[4-oxo-butanoic] acid | 67879-06-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4,4'-(1,6-hexanediyldiimino)bis[4-oxo-butanoic] acid
• 英文别名: 4-({6-[(3-Carboxypropanoyl)amino]hexyl}amino)-4-oxobutanoic acid；4-[6-(3-carboxypropanoylamino)hexylamino]-4-oxobutanoic acid
• CAS: 67879-06-5
• 化学式: C₁₄H₂₄N₂O₆
• 分子量: 316.354
• InChiKey: SFTAUCUOSGGSBV-UHFFFAOYSA-N

物化性质

• 熔点：
  114 °C
• 沸点：
  701.0±55.0 °C(Predicted)
• 密度：
  1.213±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丁二酸酐 、 1,6-己二胺 以 水 为溶剂， 反应 6.0h， 以50%的产率得到4,4'-(1,6-hexanediyldiimino)bis[4-oxo-butanoic] acid
  参考文献：
  名称：

  十二元环二酰胺1,6-二氮杂环十二烷-2,5-二酮的制备，表征和共聚

  摘要：

  以相当高的收率（〜45％）成功合成了尼龙64的12元环状二酰胺单体。改变合成条件以观察二胺和琥珀酰氯反应物对产率的影响。三倍过量的1,6-六亚甲基二胺（HDA）可获得最高的收率，而进一步增加HDA的量则会降低收率。使用N，N-二异丙基乙胺作为除酸剂导致形成了两种不同的环酰胺，并通过1 H和13进行了全面分析C溶液核磁共振波谱法和质谱法。在差示扫描量热分析中，环状酰胺与ε-己内酰胺通过阴离子途径共聚得到具有两个不同吸热峰的嵌段共聚酰胺。然而，通过水解途径的共聚仅得到具有末端64个单元的尼龙6。©2013 Wiley Periodicals，Inc. J. Polym。科学，A部分：Polym。化学 2014，52，96-103

  DOI：

  10.1002/pola.26975

文献信息

• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS
  申请人：Chodorowski-Kimmes Sandrine

  公开号：US20100239509A1

  公开（公告）日：2010-09-23

  The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups; of a monocarboxylic acid containing 6 to 32 carbon atoms; of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and (b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

  本专利申请涉及一种化妆品或皮肤科学组合物，包括在化妆品或皮肤科学上可接受的介质中，包含以下聚合物的组合物：(a) 由以下反应得到的聚合物骨架：含有3至6个羟基的多元醇；含有6至32个碳原子的一元羧酸；至少含有两个羧基COOH的多元羧酸，和/或类似多元羧酸的环酐和/或至少含有一个羧基COOH的内酯；以及(b) 至少一个连接到所述聚合物骨架的连接基团，并能够与一个或多个配对连接基团建立H键，每个连接基团的配对涉及至少三个H（氢）键。该专利申请还涉及使用所述组合物的化妆品处理过程。
• COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION
  申请人：GIUSTINIANI Pascal

  公开号：US20090028807A1

  公开（公告）日：2009-01-29

  The present application relates to a cosmetic or pharmaceutical, in particular lipstick, composition comprising a polycondensate The application also relates to a method of cosmetic treatment using the composition, the polycondensate thus defined and a method of preparing the polycondensate.

  本申请涉及一种化妆品或药用品，特别是口红，包括聚缩酸酯的组合物。该申请还涉及一种使用该组合物进行化妆处理的方法，所述聚缩酸酯的定义以及一种制备聚缩酸酯的方法。
• COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT
  申请人：Malle Gerard

  公开号：US20100272660A1

  公开（公告）日：2010-10-28

  The present application relates to a cosmetic or pharmaceutical composition comprising a polycondensate capable of being obtained by the reaction of the following monomers alone: of 10 to 30% by weight, relative to the total weight of the polycondensate, of one or more polyols comprising 3 to 6 hydroxyl groups; of 30 to 80% by weight, relative to the total weight of the polycondensate, of one or more linear, branched and/or cyclic, saturated or unsaturated, non-aromatic monocarboxylic acids comprising 6 to 32 carbon atoms; of 1 to 40% by weight, relative to the total weight of the polycondensate, of one or more polycarboxylic acids and/or cyclic anhydrides of such a polycarboxylic acid and/or lactones comprising at least one COOH group; and optionally of 0.1 to 15% by weight, relative to the total weight of the polycondensate, of one or more silicones having a hydroxyl and/or carboxyl functional group. The application also relates to a method of cosmetic treatment using the said composition, and the polycondensate thus defined.

  本申请涉及一种化妆品或药用组合物，包括由以下单体反应而得的聚缩酸酯：相对于聚缩酸酯的总重量，占10至30%的一种或多种含有3至6个羟基的多元醇；占30至80%的一种或多种线性、支链和/或环状、饱和或不饱和、非芳香族的单羧酸，含有6至32个碳原子；占聚缩酸酯总重量的1至40%的一种或多种多羧酸和/或多羧酸的环状酐和/或含有至少一个COOH基团的内酯；以及可选地占聚缩酸酯总重量的0.1至15%的一种或多种硅氧烷，具有羟基和/或羧基官能团。该申请还涉及使用所述组合物进行化妆处理的方法，以及如此定义的聚缩酸酯。
• Katsarava, R.D.; Kharadze, D.P., Journal of general chemistry of the USSR, 1991, vol. 61, # 11.1, p. 2241 - 2246
  作者：Katsarava, R.D.、Kharadze, D.P.

  DOI：——

  日期：——
• Flemming, Christian; Gabert, Anton; Wand, Helmut, Collection of Czechoslovak Chemical Communications, 1983, vol. 48, # 1, p. 184 - 191
  作者：Flemming, Christian、Gabert, Anton、Wand, Helmut、Zemek, Jiri

  DOI：——

  日期：——