N-cyclohexyl-2,2-difluoro-3-formamido-3-phenylpropanamide | 1151687-62-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-cyclohexyl-2,2-difluoro-3-formamido-3-phenylpropanamide
• CAS: 1151687-62-5
• 化学式: C₁₆H₂₀F₂N₂O₂
• 分子量: 310.344
• InChiKey: MWVJTRSINJOKBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-cyclohexyl-2,2-difluoro-3-formamido-3-phenylpropanamide 在 四氯化碳 、 三乙胺 、 三苯基膦 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 2.0h， 以70%的产率得到N-cyclohexyl-2,2-difluoro-3-isocyano-3-phenylpropanamide
  参考文献：
  名称：

  New gem-difluoromethylene-containing isocyanide as a useful building block for the synthesis of difluorinated pseudopeptides via Ugi reaction

  摘要：

  A new and efficient method was developed for the synthesis of novel gem-difluoromethylene-containing isocyanide, which can be used as a building block for the synthesis of difluorinated pseudopeptides via Ugi reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.02.056
• 作为产物：
  描述：

  3-amino-N-cyclohexyl-2,2-difluoro-3-phenylpropanamide 、 甲酸乙酯 反应 18.0h， 以95%的产率得到N-cyclohexyl-2,2-difluoro-3-formamido-3-phenylpropanamide
  参考文献：
  名称：

  New gem-difluoromethylene-containing isocyanide as a useful building block for the synthesis of difluorinated pseudopeptides via Ugi reaction

  摘要：

  A new and efficient method was developed for the synthesis of novel gem-difluoromethylene-containing isocyanide, which can be used as a building block for the synthesis of difluorinated pseudopeptides via Ugi reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.02.056

文献信息

• New gem-difluoromethylene-containing isocyanide as a useful building block for the synthesis of difluorinated pseudopeptides via Ugi reaction
  作者：Nianjin Liu、Song Cao、Li Shen、Jingjing Wu、Jinlong Yu、Jian Zhang、Hui Li、Xuhong Qian

  DOI：10.1016/j.tetlet.2009.02.056

  日期：2009.4

  A new and efficient method was developed for the synthesis of novel gem-difluoromethylene-containing isocyanide, which can be used as a building block for the synthesis of difluorinated pseudopeptides via Ugi reaction. (C) 2009 Elsevier Ltd. All rights reserved.