N-{3-[4-(3-Amino-propylamino)-butylamino]-propyl}-butyramide | 130306-92-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-{3-[4-(3-Amino-propylamino)-butylamino]-propyl}-butyramide
• 英文别名: N-[3-[4-(3-aminopropylamino)butylamino]propyl]butanamide
• CAS: 130306-92-2
• 化学式: C₁₄H₃₂N₄O
• 分子量: 272.434
• InChiKey: YEHCADPIXAIXBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  79.2
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  精胺 生成 N-{3-[4-(3-Amino-propylamino)-butylamino]-propyl}-butyramide
  参考文献：
  名称：

  NAKANISHI, KOJI;GOODNOW, R.;KONNO, K.;NIWA, M.;BUKOWNIK, RUDOLPH;KALLIMOP+, PURE AND APPL. CHEM., 62,(1990) N, C. 1223-1230

  摘要：

  DOI：

文献信息

• Bendamustine cyclopolysaccharide compositions
  申请人：SUPRATEK PHARMA, INC.

  公开号：EP2792369A1

  公开（公告）日：2014-10-22

  The present invention is directed to pharmaceutical compositions comprising: (a) bendamustine, (b) a charged cyclopolysaccharide, and (c) a stabilizing agent having a charge opposite to that of the cyclopolysaccharide. Such composition provides unexpectedly desirable stability in reactive environments such as plasma, coupled with unexpectedly desirable anticancer activity. Such compositions are suitable for injection or infusion into patients in need for treatment with bendamustine.

  本发明涉及药物组合物，包括：(a) 苯达莫司汀；(b) 带电荷的环多糖；(c) 与环多糖电荷相反的稳定剂。这种组合物在血浆等反应性环境中具有出乎意料的理想稳定性，同时还具有出乎意料的理想抗癌活性。这种组合物适合注射或输注到需要接受苯达莫司汀治疗的患者体内。
• Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto
  申请人：THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：US11421044B2

  公开（公告）日：2022-08-23

  Several embodiments of NO releasing structures are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The covalently modified polymer structures may be tailored to release nitric oxide in a controlled manner and are useful for treatment of various medical conditions.

  本文公开了几种一氧化氮释放结构的实施方案。在某些实施方案中，这些结构经过共价修饰，可储存和释放一氧化氮。一些实施方案涉及这些结构的制造和使用方法。共价修饰的聚合物结构可定制为以受控方式释放一氧化氮，可用于治疗各种病症。
• Synthesis of glutamate receptor antagonist philanthotoxin-433 (PhTX-433) and its analogs
  作者：R. Goodnow、K. Konno、M. Niwa、T. Kallimopoulos、R. Bukownik、Deborah Lenares、K. Nakanishi

  DOI：10.1016/s0040-4020(01)85463-6

  日期：——
• NAKANISHI, KOJI;GOODNOW, R.;KONNO, K.;NIWA, M.;BUKOWNIK, RUDOLPH;KALLIMOP+, PURE AND APPL. CHEM., 62,(1990) N, C. 1223-1230
  作者：NAKANISHI, KOJI、GOODNOW, R.、KONNO, K.、NIWA, M.、BUKOWNIK, RUDOLPH、KALLIMOP+

  DOI：——

  日期：——
• BENDAMUSTINE CYCLOPOLYSACCHARIDE COMPOSITIONS
  申请人：SUPRATEK PHARMA, INC.

  公开号：EP2400987A1

  公开（公告）日：2012-01-04