α-N-Acetyllysinamid | 90228-09-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-N-Acetyllysinamid
• 英文别名: 2-Acetamido-6-aminohexanamide
• CAS: 90228-09-4
• 化学式: C₈H₁₇N₃O₂
• 分子量: 187.242
• InChiKey: RXDBWNXJJIDFEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  98.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  α-N-Acetyllysinamid 、 5-formyl-2'-deoxycytidine 以 aq. buffer 为溶剂， 反应 20.0h， 以80%的产率得到
  参考文献：
  名称：

  5-Formylcytosine Yields DNA–Protein Cross-Links in Nucleosome Core Particles

  摘要：

  In situ generation of 5-formylcytosine (SIC) in nucleosome core particles (NCPs) reveals that 5fC leads to essential DNA-protein cross-links (DPCs). Mechanistic studies using chemical models and mutated histones demonstrate that DPCs form reversibly between the formyl function of 5fC and primary amines on histones. These results suggest that DPC formation from 5fC in chromatin occurs in addition to its role in DNA demethylation.

  DOI：

  10.1021/jacs.7b05495

文献信息

• MEXILETINE PRODRUGS
  申请人：Franklin Richard

  公开号：US20120196933A1

  公开（公告）日：2012-08-02

  The present invention concerns prodrugs of mexiletine (and mexiletine's active metabolite) pharmaceutical compositions containing such prodrugs. Methods for treating myotonic conditions, while reducing the inherent adverse GI side effects associated with mexiletine, increasing the bioavailability of mexiletine, and improving the pharmacokinetic reproducibility of mexiletine with the aforementioned prodrugs are also provided.

  本发明涉及美西律定（以及美西律定的活性代谢物）的前药以及含有这些前药的药物组合物。还提供了治疗肌张力不良症的方法，同时减少与美西律定相关的固有不良胃肠副作用，增加美西律定的生物利用度，并改善美西律定的药代动力学可重复性。
• ISOTOPE-LABELED PYRYLIUM COMPOUND
  申请人：NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF FUKUI

  公开号：US20150094233A1

  公开（公告）日：2015-04-02

  The present invention provides a compound represented by the formula (I): or a salt thereof; and a method of quantitatively analyzing an amino group-containing target substance, including labeling a target substance in samples by using, as a labeling compound, two or more of such compounds having a mutually different mass due to isotope labeling, to confer a mass difference to the target substance between two or more samples, and the like.
• US9347949B2
  申请人：——

  公开号：US9347949B2

  公开（公告）日：2016-05-24