4-{4-(2,4-dichloro-phenyl)-2-[2-(3'-trifluoromethyl-biphenyl-4-yl)-(E)-vinyl]-imidazol-1-ylmethyl}-phenylamine | 863246-66-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-{4-(2,4-dichloro-phenyl)-2-[2-(3'-trifluoromethyl-biphenyl-4-yl)-(E)-vinyl]-imidazol-1-ylmethyl}-phenylamine
• 英文别名: 4-[[4-(2,4-dichlorophenyl)-2-[(E)-2-[4-[3-(trifluoromethyl)phenyl]phenyl]ethenyl]imidazol-1-yl]methyl]aniline
• CAS: 863246-66-6
• 化学式: C₃₁H₂₂Cl₂F₃N₃
• 分子量: 564.437
• InChiKey: DFDLFGGAFPNDEG-OVCLIPMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-{4-(2,4-dichloro-phenyl)-2-[2-(3'-trifluoromethyl-biphenyl-4-yl)-(E)-vinyl]-imidazol-1-ylmethyl}-phenylamine 、 甘胺酸甲酯 、 N,N'-羰基二咪唑 在 4-二甲氨基吡啶 氮气 、 silica gel 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 2.0h， 以to yield [3-(4-{4-(2,4-dichloro-phenyl)-2-[2-(3′-trifluoromethyl-biphenyl-4-yl)-(E)-vinyl]-imidazol-1-ylmethyl}-phenyl)-ureido]-acetic acid methyl ester (28 mg, 41%)的产率得到[3-(4-{4-(2,4-dichloro-phenyl)-2-[2-(3'-trifluoromethyl-biphenyl-4-yl)-(E)-vinyl]-imidazol-1-ylmethyl}-phenyl)-ureido]-acetic acid methyl ester
  参考文献：
  名称：

  Substituted azole derivatives, compositions, and methods of use

  摘要：

  本发明提供了式（I）的唑类衍生物，它们的制备方法，包含式（I）化合物的药物组合物以及它们在治疗人类或动物疾病方面的用途。本发明的化合物可用作蛋白酪氨酸磷酸酶的抑制剂，因此可用于管理、治疗、控制或辅助治疗PTPase活性介导的疾病，这些疾病包括I型糖尿病和II型糖尿病。

  公开号：

  US20050187277A1

文献信息

• Substituted azole derivatives, compositions, and methods of use
  申请人：Mjalli M.M. Adnan

  公开号：US20050187277A1

  公开（公告）日：2005-08-25

  The present invention provides azole derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and their use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of protein tyrosine phosphatases and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases mediated by PTPase activity. Such diseases include Type I diabetes and Type II diabetes.

  本发明提供了式（I）的唑类衍生物，其制备方法，包含式（I）化合物的药物组合物，以及它们在治疗人类或动物疾病中的用途。本发明的化合物可用作蛋白酪氨酸磷酸酶的抑制剂，因此可用于管理、治疗、控制或辅助治疗由PTPase活性介导的疾病。这些疾病包括I型糖尿病和II型糖尿病。
• SUBSTITUTED AZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE
  申请人：Transtech Pharma, Inc.

  公开号：EP1730118A1

  公开（公告）日：2006-12-13
• [EN] SUBSTITUTED AZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE<br/>[FR] DERIVES D'AZOLE SUBSTITUES, COMPOSITIONS, ET PROCEDES D'UTILISATION
  申请人：TRANSTECH PHARMA INC

  公开号：WO2005080346A1

  公开（公告）日：2005-09-01

  The present invention provides azole derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and their use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of protein tyrosine phosphatases and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases mediated by PTPase activity. Such diseases include Type I diabetes and Type II diabetes.
• Substituted Azole Derivatives, Compositions, and Methods of Use
  申请人：Mjalli Adnan M.M.

  公开号：US20110092553A1

  公开（公告）日：2011-04-21

  The present invention provides azole derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and their use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of protein tyrosine phosphatases and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases mediated by PTPase activity. Such diseases include Type I diabetes and Type II diabetes.

  本发明提供式（I）的唑类衍生物，其制备方法，含有式（I）化合物的制药组合物，以及它们在治疗人类或动物疾病方面的用途。本发明的化合物可用作蛋白酪氨酸磷酸酶的抑制剂，因此可用于治疗PTPase活性介导的疾病的管理、治疗、控制或辅助治疗。这些疾病包括1型糖尿病和2型糖尿病。