chlorophyll d | 519-63-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: chlorophyll d
• 英文别名: magnesium;methyl (3R,21S,22S)-11-ethyl-16-formyl-12,17,21,26-tetramethyl-4-oxo-22-[3-oxo-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enoxy]propyl]-23,25-diaza-7,24-diazanidahexacyclo[18.2.1.15,8.110,13.115,18.02,6]hexacosa-1,5,8(26),9,11,13(25),14,16,18,20(23)-decaene-3-carboxylate
• CAS: 519-63-1
• 化学式: C₅₄H₇₀MgN₄O₆
• 分子量: 895.478
• InChiKey: QXWRYZIMSXOOPY-SKHCYZARSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  12.01
• 重原子数：
  65
• 可旋转键数：
  22
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  chlorophyll d 在 盐酸 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 Pheo-d
  参考文献：
  名称：

  Effects of molecular structures on reduction properties of formyl groups in chlorophylls and pheophytins prepared from oxygenic photosynthetic organisms

  摘要：

  Reduction of the 7-formyl groups in chlorophyll (Chl) b and its demetalated compound pheophytin (Phe) b was kinetically analyzed by using tert-butylamine-borane complex (t-BuNH2 center dot BH3), and was compared with that of the 3-formyl groups in Chl d and Phe d. Reduction kinetics of the 7-formyl group in Chl b was similar to that in Phe b in dichloromethane containing 5 mM t-BuNH2 center dot BH3. Little difference of the reduction kinetics of the 7-formyl groups between Chl b and Phe b was in sharp contrast to the reduction kinetics of the 3-formyl groups in Chl d and Phe d: the 3-formyl group in Phe d was reduced 5.3-fold faster than that in Chl d. The 7-formyl groups in Chl b and Phe b were reduced more slowly than the 3-formyl groups in Chl d and Phe d, respectively. The difference of the reactivity between the 3- and 7-formyl groups was in line with C-13 NMR measurements of chlorophyllous pigments, in which the chemical shifts of carbon atoms in the 7-formyl groups of Chl b and Phe b were high-field shifted compared with those in the 3-formyl groups of Chl d and Phe d, respectively. These indicate that the 7-formyl groups in chlorophyllous pigments were less reactive for reduction to the corresponding hydroxymethyl groups than the 3-formyl groups due to the difference in electronic states of the formyl groups in the A-and B-rings of the chlorin macrocycle. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.05.039
• 作为产物：
  描述：

  chlorophyll a 在 氧气 、 苯硫酚 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 24.75h， 以31%的产率得到chlorophyll d
  参考文献：
  名称：

  Ene-thiol reaction of C3-vinylated chlorophyll derivatives in the presence of oxygen: synthesis of C3-formyl-chlorins under mild conditions

  摘要：

  研究了硫醇与各种叶绿素（Chl）衍生物的 C 3-乙烯基的反应。这些反应类似于硫醇与烯烃的共氧化反应，只是乙烯基 C = C 双键在没有任何过渡金属催化剂的情况下被裂解以产生甲酰基，而且硫醇与烯烃的简单反马尔科夫尼科夫加合物作为次要产物被获得。Chl 衍生物的外围取代基对反应的影响很小，而氯素大环的中心金属原子则会影响产物的组成。溶解在反应混合物中的氧气和酸可促进氧化。在这种 C 31 位的区域选择性氧化反应中，足够温和的条件在生物有机化学中具有重要意义。

  DOI：

  10.1142/s1088424613500983

文献信息

• IMIDAZOPYRIDINES SYK INHIBITORS
  申请人：Blomgren Peter A.

  公开号：US20140148430A1

  公开（公告）日：2014-05-29

  Certain imidazopyridines (I) and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.

  本文提供了某些咪唑吡啶(I)及其药物组合物。提供了治疗对Syk活性抑制敏感的患者患有某些疾病和疾病的方法，包括向这些患者施用至少一种有效减轻疾病或疾病症状的化学实体。还提供了一种确定样本中Syk激酶存在或不存在的方法。
• [EN] INHIBITING HYDROCARBON HYDRATE AGGLOMERATION<br/>[FR] INHIBITION DE L'AGGLOMÉRATION D'HYDRATES D'HYDROCARBURES
  申请人：COMMW SCIENT IND RES ORG

  公开号：WO2018218281A1

  公开（公告）日：2018-12-06

  A process for inhibiting the formation of gas hydrates in a hydrocarbon fluid comprising adding to the hydrocarbon fluid, a gas hydrate anti-agglomerate which is a biodegradable anti-agglomerant derived from a naturally occurring substance.

  一种抑制碳氢化合物流体中天然气水合物形成的方法包括向碳氢化合物流体中添加一种气体水合物抗凝聚剂，该抗凝聚剂是一种可生物降解的抗凝聚剂，来源于天然存在的物质。
• Semi-synthesis and HPLC analysis of (bacterio)chlorophyllides possessing a propionic acid residue at the C17-position
  作者：Misato Teramura、Hitoshi Tamiaki

  DOI：10.1142/s1088424618500347

  日期：2018.5

  Various chlorophyll and bacteriochlorophyll derivatives possessing a magnesium or zinc atom at the central position and a free carboxylic acid group at the C17[Formula: see text]-position, also known as (bacterio)chlorophyllides, were synthesized through a combination of organic synthesis techniques and enzymatic steps. The semi-synthetic (bacterio)chlorophyllides were purified and analyzed using reversed-phase high-performance liquid chromatography with UV-vis spectroscopy and mass spectrometry. These free propionic acid-containing chlorophyllous pigments can be useful research materials for the study of (bacterio)chlorophyll metabolisms.

  通过有机合成技术和酶解步骤的结合，合成了多种叶绿素和细菌叶绿素衍生物，这些衍生物的中心位置有一个镁或锌原子，C17[式：见正文]位置有一个游离的羧酸基团，也称为（细菌）叶绿素化物。采用反相高效液相色谱法、紫外-可见光谱法和质谱法对半合成（细菌）叶绿素化物进行了纯化和分析。这些含游离丙酸的叶绿素色素可作为研究（细菌）叶绿素代谢的有用研究材料。
• Ene-thiol reaction of <font>C</font>3-vinylated chlorophyll derivatives in the presence of oxygen: synthesis of <font>C</font>3-formyl-chlorins under mild conditions
  作者：Takanori Fukusumi、Natsuki Takei、Yubi Tateno、Takuya Aoki、Ai Ando、Kouhei Kozakai、Hiroko Shima、Tadashi Mizoguchi、Satoshi Ito、Tsukasa Ikeda、Hitoshi Tamiaki、Toru Oba

  DOI：10.1142/s1088424613500983

  日期：2013.12

  Reactions of thiol with the C 3-vinyl group of various chlorophyll (Chl) derivatives were examined. The reactions resemble thiol-olefin co-oxidation, except that the vinyl C = C double bond was cleaved to afford a formyl group without any transition metal catalyst, and that the simple anti-Markovnikov adduct of thiol to olefin was obtained as a minor product. Peripheral substituents of Chl derivatives little affected the reaction, while the central metal atom of the chlorin macrocycle influenced the composition of the products. Oxygen and acid dissolved in the reaction mixture can facilitate the oxidation. Sufficiently mild conditions in this regioselective oxidation at the C 3¹-position are significant in bioorganic chemistry.

  研究了硫醇与各种叶绿素（Chl）衍生物的 C 3-乙烯基的反应。这些反应类似于硫醇与烯烃的共氧化反应，只是乙烯基 C = C 双键在没有任何过渡金属催化剂的情况下被裂解以产生甲酰基，而且硫醇与烯烃的简单反马尔科夫尼科夫加合物作为次要产物被获得。Chl 衍生物的外围取代基对反应的影响很小，而氯素大环的中心金属原子则会影响产物的组成。溶解在反应混合物中的氧气和酸可促进氧化。在这种 C 31 位的区域选择性氧化反应中，足够温和的条件在生物有机化学中具有重要意义。
• AMIDE DERIVATIVE AND USE THEREOF
  申请人：Ushio Hiroyuki

  公开号：US20130211075A1

  公开（公告）日：2013-08-15

  The present invention relates to a novel amide derivative. More specifically, the present invention provides a medicinal agent useful as a prophylactic or therapeutic agent for diseases, which relies on the production of cytokines from T cells, and which comprises an amide derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or the pharmacologically acceptable salt as an active ingredient. Provided is an amide derivative represented by general formula (I) [wherein each symbol is as defined in the description] or a pharmacologically acceptable salt thereof, or a solvate of the derivative or the pharmacologically acceptable salt.

  本发明涉及一种新型酰胺衍生物。更具体地说，本发明提供了一种药用剂，可用作依赖于T细胞产生细胞因子的疾病的预防或治疗剂，该药用剂包括酰胺衍生物或其药理学上可接受的盐或该衍生物或药理学上可接受的盐的溶剂的溶剂作为活性成分。提供的是由通式(I)所表示的酰胺衍生物[其中每个符号如描述中所定义]或其药理学上可接受的盐，或该衍生物或药理学上可接受的盐的溶剂。