(R)-tert-butyl (1-methyl-2-oxo-3-(prop-2-yn-1-yloxy)indolin-3-yl)carbamate | 1448538-70-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-tert-butyl (1-methyl-2-oxo-3-(prop-2-yn-1-yloxy)indolin-3-yl)carbamate
• 英文别名: tert-butyl N-[(3R)-1-methyl-2-oxo-3-prop-2-ynoxyindol-3-yl]carbamate
• CAS: 1448538-70-2
• 化学式: C₁₇H₂₀N₂O₄
• 分子量: 316.357
• InChiKey: DFCKLKRMSXVCGT-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  tert-butyl 1-methyl-2-oxoindolin-3-ylidenecarbamate 、 2-丙炔-1-醇 在 N-[3,5-双(三氟甲基)苯基]-N'-[(8a,9S)-6'-甲氧基-9-金鸡宁]硫脲 作用下， 以 乙腈 为溶剂， 以56%的产率得到
  参考文献：
  名称：

  Catalytic enantioselective addition of alcohols to isatin-derived N-Boc ketimines

  摘要：

  The enantioselective addition of alcohols to isatin-derived N-Boc ketimines was investigated for the first time. Isatin-derived N,O-aminals were obtained in excellent yields with moderate-to-good enantiose-lectivities (up to 78% ee) in the presence of a quinine-based bifunctional catalyst. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.06.076

文献信息

• The 2′-phenyl cinchonidine thiourea-catalyzed asymmetric addition of alcohols to isatin-derived N-Boc ketimines
  作者：Jing Liu、Fang-Meng Zhu、Yun-Bo Chu、Li-Hong Huang、Yi-Feng Zhou

  DOI：10.1016/j.tetasy.2015.08.011

  日期：2015.11

  Optically active isatin-derived N,0-aminals were obtained through the catalytic asymmetric addition of various alcohols to isatin-derived N-Boc ketimines. Using 2'-phenyl cinchonidine thiourea as the catalyst, adducts were obtained in 96% yield and with up to 92% ee. (C) 2015 Elsevier Ltd. All rights reserved.