N-myristoyl-L-asparagine | 133867-18-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-myristoyl-L-asparagine
• 英文别名: Myristoyl-asparagine；(2S)-4-amino-4-oxo-2-(tetradecanoylamino)butanoic acid
• CAS: 133867-18-2
• 化学式: C₁₈H₃₄N₂O₄
• 分子量: 342.479
• InChiKey: XCYGCBVZSVXYON-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 以92%的产率得到N-myristoyl-L-asparagine
  参考文献：
  名称：

  从pks岛中分离出代谢物，可深入了解Colibactin的生物合成和活性

  摘要：

  Colibactin是由共生和致病菌株产生结构上未表征的，基因毒性的天然产物的大肠杆菌窝藏的PKS岛。从pks +大肠杆菌突变体中分离出一种新的代谢物，该突变体缺少必不可少的生物合成酶。该分子的不寻常的azaspiro [2.4]双环系统为大肠菌素的生物合成提供了新的见识，并提出了大肠菌素和其他pks衍生代谢物可能通过其产生遗传毒性的机制。

  DOI：

  10.1021/acs.orglett.5b00432

文献信息

• Correction to Isolation of a Metabolite from the <i>pks</i> Island Provides Insights into Colibactin Biosynthesis and Activity
  作者：Carolyn A. Brotherton、Matthew Wilson、Gary Byrd、Emily P. Balskus

  DOI：10.1021/acs.orglett.5b01056

  日期：2015.5.1

  Revised file containing corrections to the chemical shifts in Table S3. This material is available free of charge via the Internet at http://pubs.acs.org. This article is cited by 3 publications. Revised file containing corrections to the chemical shifts in Table S3. This material is available free of charge via the Internet at http://pubs.acs.org.

  经修订的文件，其中包含对表S3中化学位移的更正。该材料可通过互联网（http://pubs.acs.org）免费获得。这篇文章被3个出版物引用。经修订的文件，其中包含对表S3中化学位移的更正。该材料可通过互联网（http://pubs.acs.org）免费获得。
• CLEANSING COMPOSITION
  申请人：——

  公开号：US20010055576A1

  公开（公告）日：2001-12-27

  The present invention relates to a cleansing composition comprising at least one compound selected from N-long chain acylamino acids represented by formula (I): 1 (wherein n represents 1 or 2; and R represents a saturated or unsaturated hydrocarbon group having 5 to 23 carbon atoms), and salts thereof.

  本发明涉及一种清洁组合物，其包含至少一种选择自式(I)所表示的N-长链酰胺酸化合物（其中n代表1或2；R代表具有5至23个碳原子的饱和或不饱和碳氢基团）及其盐。
• Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules
  作者：Maria I. Vizcaino、Philipp Engel、Eric Trautman、Jason M. Crawford

  DOI：10.1021/ja503450q

  日期：2014.7.2

  The gene duster responsible for synthesis of the unknown molecule "colibactin" has been identified in mutualistic and pathogenic Escherichia coli. The pathway endows its producer with a long-term persistence phenotype in the human bowel, a probiotic activity used in the treatment of ulcerative colitis, and a carcinogenic activity under host inflammatory conditions. To date, functional small molecules from this pathway have not been reported. Here we implemented a comparative metabolomics and targeted structural network analyses approach to identify a catalog of small molecules dependent on the colibactin pathway from the meningitis isolate E. coli IHE3034 and the probiotic E. coli Nissle 1917. The structures of 10 pathway-dependent small molecules are proposed based on structural characterizations and network relationships. The network will provide a roadmap for the structural and functional elucidation of a variety of other small molecules encoded by the pathway. From the characterized small molecule set, in vitro bacterial growth inhibitory and mammalian CNS receptor antagonist activities are presented.
• AN ENZYME-CATALYZED PROCESS FOR PREPARING N-ACYL AMINO ACIDS AND N-ACYL AMINO ACID AMIDES
  申请人：NOVO NORDISK A/S

  公开号：EP0473700A1

  公开（公告）日：1992-03-11
• US6350783B2
  申请人：——

  公开号：US6350783B2

  公开（公告）日：2002-02-26