Tert-butyl-dimethyl-[4-[4-methyl-5-tri(propan-2-yl)silyloxyfuran-3-yl]phenoxy]silane | 1278561-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl-dimethyl-[4-[4-methyl-5-tri(propan-2-yl)silyloxyfuran-3-yl]phenoxy]silane
• CAS: 1278561-38-8
• 化学式: C₂₆H₄₄O₃Si₂
• 分子量: 460.805
• InChiKey: WXRSSVDWDXTTNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.19
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  31.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl-dimethyl-[4-[4-methyl-5-tri(propan-2-yl)silyloxyfuran-3-yl]phenoxy]silane 在 二甲基二环氧乙烷 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Concise, regiocontrolled synthesis of yangjinhualine A

  摘要：

  The first synthesis of yangjinhualine A, a recently isolated alpha,beta-disubstituted gamma-hydroxybutenolide from the Chinese medicinal herb Datura mete! L., has been accomplished in concise, entirely regiocontrolled fashion through the combined use of Suzuki-Miyaura cross-coupling and 2-silyloxyfuran oxyfunctionalization. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.036
• 作为产物：
  描述：

  4-羟基-3-甲基-5H-呋喃-2-酮 在 palladium diacetate 、 sodium carbonate 、 三乙胺 、 三环己基膦 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 6.0h， 生成 Tert-butyl-dimethyl-[4-[4-methyl-5-tri(propan-2-yl)silyloxyfuran-3-yl]phenoxy]silane
  参考文献：
  名称：

  Concise, regiocontrolled synthesis of yangjinhualine A

  摘要：

  The first synthesis of yangjinhualine A, a recently isolated alpha,beta-disubstituted gamma-hydroxybutenolide from the Chinese medicinal herb Datura mete! L., has been accomplished in concise, entirely regiocontrolled fashion through the combined use of Suzuki-Miyaura cross-coupling and 2-silyloxyfuran oxyfunctionalization. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.036

文献信息

• Concise, regiocontrolled synthesis of yangjinhualine A
  作者：John Boukouvalas、Lucas C. McCann

  DOI：10.1016/j.tetlet.2011.01.036

  日期：2011.3

  The first synthesis of yangjinhualine A, a recently isolated alpha,beta-disubstituted gamma-hydroxybutenolide from the Chinese medicinal herb Datura mete! L., has been accomplished in concise, entirely regiocontrolled fashion through the combined use of Suzuki-Miyaura cross-coupling and 2-silyloxyfuran oxyfunctionalization. (C) 2011 Elsevier Ltd. All rights reserved.