Asp-Leu-Lys-Glu-Arg-Lys-Asp-Val-Tyr | 123167-52-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Asp-Leu-Lys-Glu-Arg-Lys-Asp-Val-Tyr
• 英文别名: (4S)-4-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-5-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
• CAS: 123167-52-2
• 化学式: C₅₁H₈₄N₁₄O₁₇
• 分子量: 1165.31
• InChiKey: GXPBJVNQBZKWQI-QMSQUTIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -10
• 重原子数：
  82
• 可旋转键数：
  41
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  545
• 氢给体数：
  18
• 氢受体数：
  21

反应信息

• 作为产物：
  描述：

  在 氢氟酸 作用下， 以 various solvent(s) 为溶剂， 反应 0.67h， 生成 Asp-Leu-Lys-Glu-Arg-Lys-Asp-Val-Tyr
  参考文献：
  名称：

  Thymosin-like peptides as potential immunostimulants. Synthesis via the polymeric-reagent method

  摘要：

  This paper reports our attempt at designing new immunostimulating peptides which are chemically related to the bioactive peptides thymosin alpha 1 and thymopentin. Three peptides were synthesized, Asp-Leu-Lys-Glu-Arg-Lys-Asp-Val-Tyr (3), Arg-Lys-Asp-Val-Tyr-Glu-Glu-Ala-Glu-Asn (2), and Asp-Leu-Lys-Glu-Arg-Lys-Asp-Val-Tyr-Glu-Glu-Ala-Glu-Asn (1), each of which contains the thymopentin sequence and portions of the bioactive sequence of thymosin alpha 1. Peptides 1-3 were assembled from selected blocked fragments that were synthesized by the polymeric-reagent method, using PHBT (polystyrene-bound 1-hydroxybenzotriazole) as the activating polymer. The ability of peptides 1-3 to enhance the activation (RNA synthesis) and proliferation (DNA synthesis) of human T lymphocytes was determined. In comparison to thymosin alpha 1, thymosin alpha 1 (15-28), and thymopentin, peptides 1-3 did not show significant enhancement of these processes.

  DOI：

  10.1021/jm00163a057

文献信息

• MOKOTOFF, MICHAEL;ZHAO, MING;ROTH, STEVEN M.;SHELLEY, JEAN A.;SLAVOSKI, J+, J. MED. CHEM., 33,(1990) N, C. 354-360
  作者：MOKOTOFF, MICHAEL、ZHAO, MING、ROTH, STEVEN M.、SHELLEY, JEAN A.、SLAVOSKI, J+

  DOI：——

  日期：——
• Thymosin-like peptides as potential immunostimulants. Synthesis via the polymeric-reagent method
  作者：Michael Mokotoff、Ming Zhao、Steven M. Roth、Jean A. Shelley、Joseph N. Slavoski、Nicola M. Kouttab

  DOI：10.1021/jm00163a057

  日期：1990.1

  This paper reports our attempt at designing new immunostimulating peptides which are chemically related to the bioactive peptides thymosin alpha 1 and thymopentin. Three peptides were synthesized, Asp-Leu-Lys-Glu-Arg-Lys-Asp-Val-Tyr (3), Arg-Lys-Asp-Val-Tyr-Glu-Glu-Ala-Glu-Asn (2), and Asp-Leu-Lys-Glu-Arg-Lys-Asp-Val-Tyr-Glu-Glu-Ala-Glu-Asn (1), each of which contains the thymopentin sequence and portions of the bioactive sequence of thymosin alpha 1. Peptides 1-3 were assembled from selected blocked fragments that were synthesized by the polymeric-reagent method, using PHBT (polystyrene-bound 1-hydroxybenzotriazole) as the activating polymer. The ability of peptides 1-3 to enhance the activation (RNA synthesis) and proliferation (DNA synthesis) of human T lymphocytes was determined. In comparison to thymosin alpha 1, thymosin alpha 1 (15-28), and thymopentin, peptides 1-3 did not show significant enhancement of these processes.