N-[3,5-Dimethoxy-2-(2-methoxy-acetyl)-phenyl]-4-fluoro-benzamide | 305834-43-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3,5-Dimethoxy-2-(2-methoxy-acetyl)-phenyl]-4-fluoro-benzamide
• 英文别名: N-[3,5-dimethoxy-2-(2-methoxyacetyl)phenyl]-4-fluorobenzamide
• CAS: 305834-43-9
• 化学式: C₁₈H₁₈FNO₅
• 分子量: 347.343
• InChiKey: PLFWJIUBIBIBBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-[3,5-Dimethoxy-2-(2-methoxy-acetyl)-phenyl]-4-fluoro-benzamide 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 160.0~165.0 ℃ 、1.24 MPa 条件下， 生成 2-(4-Fluoro-phenyl)-3,5,7-trimethoxy-1H-quinolin-4-one
  参考文献：
  名称：

  Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones11Part of the work was presented at the XIVth International Symposium on Medicinal Chemistry, Maastricht, NL, 1996 (Abst. P–10.17)

  摘要：

  A series of aza-flavones (3-hydroxy-2-phenyl-4-quinolones) were designed and synthesized as inhibitors of bacterial DNA-gyrase and mammalian topoisomerase II. Structure activity relationships of the compounds against each of the enzymes are discussed. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80087-7
• 作为产物：
  描述：

  3,5-二甲氧基苯胺 在 吡啶 、 三氯化硼 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 23.75h， 生成 N-[3,5-Dimethoxy-2-(2-methoxy-acetyl)-phenyl]-4-fluoro-benzamide
  参考文献：
  名称：

  Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones11Part of the work was presented at the XIVth International Symposium on Medicinal Chemistry, Maastricht, NL, 1996 (Abst. P–10.17)

  摘要：

  A series of aza-flavones (3-hydroxy-2-phenyl-4-quinolones) were designed and synthesized as inhibitors of bacterial DNA-gyrase and mammalian topoisomerase II. Structure activity relationships of the compounds against each of the enzymes are discussed. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80087-7

文献信息

• Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones11Part of the work was presented at the XIVth International Symposium on Medicinal Chemistry, Maastricht, NL, 1996 (Abst. P–10.17)
  作者：Zhihua Sui、Van N Nguyen、Jason Altom、Jeffrey Fernandez、Jamese J Hilliard、Jeffrey I Bernstein、John F Barrett、Kwasi A Ohemeng

  DOI：10.1016/s0223-5234(99)80087-7

  日期：1999.5

  A series of aza-flavones (3-hydroxy-2-phenyl-4-quinolones) were designed and synthesized as inhibitors of bacterial DNA-gyrase and mammalian topoisomerase II. Structure activity relationships of the compounds against each of the enzymes are discussed. (C) Elsevier, Paris.
• A convenient method for the synthesis of 3,5,7-trimethoxy-2-phenyl-4-quinolones
  作者：Chantal Beney、Mohamed Hadjeri、Anne-Marie Mariotte、Ahcène Boumendjel

  DOI：10.1016/s0040-4039(00)01226-0

  日期：2000.9

  The synthesis of 2-aryl-3,5,7-trimethoxy-4-quinoiones was accomplished in three steps starting from 3,5-dimethoxyaniline and an aroyl chloride. These structures might be used as potential flavonol analogs. (C) 2000 Elsevier Science Ltd. All rights reserved.