3,3'-Pyridinyliden-(2)-bis-(6-brom-4-hydroxy-cumarin) | 95943-30-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3,3'-Pyridinyliden-(2)-bis-(6-brom-4-hydroxy-cumarin)
• 英文别名: 6,6'-dibromo-4,4'-dihydroxy-3,3'-pyridin-2-ylmethanediyl-bis-chromen-2-one；6-Bromo-3-[(6-bromo-4-hydroxy-2-oxochromen-3-yl)-pyridin-2-ylmethyl]-4-hydroxychromen-2-one
• CAS: 95943-30-9
• 化学式: C₂₄H₁₃Br₂NO₆
• 分子量: 571.178
• InChiKey: DSAKMFUVPMIWDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  吡啶-2-甲醛 、 6-溴-4-羟基香豆素 以 乙醇 为溶剂， 生成 3,3'-Pyridinyliden-(2)-bis-(6-brom-4-hydroxy-cumarin)
  参考文献：
  名称：

  某些4-羟基香豆素及其缩合物与醛和羧酸的合成。一些4-羟基香豆素衍生物的抗凝活性。

  摘要：

  DOI：

  10.1021/jm00333a008

文献信息

• Bis-(Coumarin) Compounds With Anti-Inflammatory Activity
  申请人：Mercep Mladen

  公开号：US20080153872A1

  公开（公告）日：2008-06-26

  Certain bis-(coumarin) compounds as well as the products of their intramolecular cyclization including pharmaceutically acceptable salts, hydrates, solvates, clathrates, prodrugs, tautomers and stereoisomers thereof are disclosed. Certain processes and intermediates for the preparation of certain bis-(coumarin) compounds, as well as for the use of these compounds as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diseases and conditions in mammals, especially humans are also disclosed.
• Syntheses of Some 4-Hydroxycoumarins and Their Condensation Products with Aldehydes and Carboxylic Acids. The Anticoagulant Activity of Some 4-Hydroxycoumarin Derivatives
  作者：Mladen Deželić、Mladen Trkovnik

  DOI：10.1021/jm00333a008

  日期：1964.5