2-Butyl-3-hydroxybutanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 2-Butyl-3-hydroxybutanedioic acid
• 化学式: C₈H₁₄O₅
• 分子量: 190.19
• InChiKey: MQVBPERQKIUJRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Genetically modified isopropylmalate isomerase enzyme complexes and processes to prepare elongated 2-ketoacids and C5-C10 compounds therewith
  申请人：Dow Global Technologies LLC

  公开号：US11230705B2

  公开（公告）日：2022-01-25

  Genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms including genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′), and processes for preparing C7-C11 2-ketoacids with genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′). The genetically modified isopropylmalate isomerase enzyme complexes (e.g., LeuCD′ enzyme complexes), microbial organisms, and processes for preparing C7-C11 2-ketoacids can be used to produce C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.

  转基因异丙基丙二酸异构酶酶复合物(如LeuCD′酶复合物)、包括转基因异丙基丙二酸异构酶酶复合物(如LeuCD′)在内的微生物、以及用转基因异丙基丙二酸异构酶酶复合物(如LeuCD′)制备C7-C11 2-酮酸的工艺。转基因异丙基丙二酸异构酶复合物（如LeuCD′酶复合物）、微生物和制备C7-C11 2-酮酸的工艺可用于在体内和体外生产C6-C10醛、烷、醇和羧酸。
• Process to prepare elongated 2-ketoacids and C-5-C10 compounds therefrom via genetic modifications to microbial metabolic pathways
  申请人：Dow Global Technologies LLC

  公开号：US11236310B2

  公开（公告）日：2022-02-01

  Genetically modified LeuCD′ enzyme complexes, processes for preparing a C7-C11 2-ketoacid utilizing genetically modified LeuCD′ enzyme complexes, and microbial organisms including modified LeuCD enzyme complexes are described. The instantly-disclosed genetically modified LeuCD′ enzyme complexes, processes for preparing a C7-C11 2-ketoacid, and microbial organisms including modified LeuCD′ enzyme complexes can be particularly useful for producing C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.

  描述了转基因LeuCD′酶复合物、利用转基因LeuCD′酶复合物制备C7-C11 2-酮酸的工艺以及包括转基因LeuCD酶复合物的微生物。即刻公开的转基因 LeuCD′ 酶复合物、制备 C7-C11 2-酮酸的工艺和包括改良 LeuCD′ 酶复合物的微生物在体内和体外生产 C6-C10 醛、烷烃、醇和羧酸方面特别有用。
• PROCESSES TO PREPARE ELONGATED 2-KETOACIDS AND C6-C10 COMPOUNDS THEREFROM VIA GENETIC MODIFICATIONS TO MICROBIAL METABOLIC PATHWAYS
  申请人：Dow Global Technologies LLC

  公开号：EP3080285A1

  公开（公告）日：2016-10-19
• PROCESSES TO PREPARE ELONGATED 2-KETOACIDS AND C-5-C10 COMPOUNDS THEREFROM VIA GENETIC MODIFICATIONS TO MICROBIAL METABOLIC PATHWAYS
  申请人：Dow Global Technologies LLC

  公开号：EP3519579A1

  公开（公告）日：2019-08-07
• GENETICALLY MODIFIED ISOPROPYLMALATE ISOMERASE ENZYME COMPLEXES AND PROCESSES TO PREPARE ELONGATED 2-KETOACIDS AND C5-C10 COMPOUNDS THEREWITH
  申请人：Dow Global Technologies LLC

  公开号：EP3688175A1

  公开（公告）日：2020-08-05