O-[(2,4-Dimethoxyphenyl)methyl]-N-(2-nitrophenylsulfonyl)hydroxylamine | 256484-97-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: O-[(2,4-Dimethoxyphenyl)methyl]-N-(2-nitrophenylsulfonyl)hydroxylamine
• 英文别名: N-[(2,4-dimethoxyphenyl)methoxy]-2-nitrobenzenesulfonamide
• CAS: 256484-97-6
• 化学式: C₁₅H₁₆N₂O₇S
• 分子量: 368.367
• InChiKey: DPMBVUICXXPRMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  O-[(2,4-Dimethoxyphenyl)methyl]-N-(2-nitrophenylsulfonyl)hydroxylamine 、 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents

  摘要：

  A solid-phase approach for the total synthesis of methyl carboxymycobactins 1a-d, with an on-resin cyclization leading to azopine 5 as the key step, was developed. The iron-affinity of these compounds was assessed by a competitive sulfoxine-binding assay, and antimycobacterial activity was tested against the growth of Mycobacterium avium. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00473-6
• 作为产物：
  描述：

  2,4-二甲氧基苄醇 在 吡啶 、 三苯基膦 、 甲基肼 、 偶氮二甲酸二乙酯 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 40.0h， 生成 O-[(2,4-Dimethoxyphenyl)methyl]-N-(2-nitrophenylsulfonyl)hydroxylamine
  参考文献：
  名称：

  O-Protected N-(2-Nitrophenylsulfonyl)hydroxylamines: Novel Reagents for the Synthesis of Hydroxamates

  摘要：

  本文描述了新型O保护N-(2-硝基苯磺酰)羟胺（8a-e）的制备方法。它们作为多羟肟酸中间体的多功能性通过合成一种非酰胺的DFO类似物22得到了体现。

  DOI：

  10.1055/s-2001-14567

文献信息

• LIBRARIES OF POLYHYDROXAMATES AND THEIR ANALOGS
  申请人：Metaphore, Inc.

  公开号：EP1098659A2

  公开（公告）日：2001-05-16
• EP1098659A4
  申请人：——

  公开号：EP1098659A4

  公开（公告）日：2004-11-24
• [EN] LIBRARIES OF POLYHYDROXAMATES AND THEIR ANALOGS<br/>[FR] BANQUES DE POLYHYDROXAMATES ET LEURS ANALOGUES
  申请人：METAPHORE INC

  公开号：WO2000004868A2

  公开（公告）日：2000-02-03

  A method of synthesizing desired polyhydroxamates and polyhydroxamate analogs is provided. The method comprises linking a first component of the desired polyhydroxamate or polyhydroxamate analog to a support matrix under conditions effective to form a first matrix-bound intermediate of said desired polyhydroxamate or analog, extending said first matrix-bound intermediate using reagents and reaction conditions effective to form one or more additional matrix-bound intermediates of said desired polyhydroxamate or analog, thereby forming a matrix-bound precursor of the desired polyhydroxamate or polyhydroxamate analog. Protective groups used during synthesis of the precursor are removed and the matrix-bound precursor is cleared from the support matrix, thereby synthesizing the desired polyhydroxamate or polyhydroxamate analog. Methods of making, screening and selecting libraries of candidate polyhydroxamates, the libraries and polyhydroxamates, polyhydroxamate analogs, their intermediates, and methods for using such compounds and their compositions are also disclosed.