4-Amino-1-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidin-2(1h)-one | 74958-34-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: 4-Amino-1-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidin-2(1h)-one
• 英文别名: 4-amino-1-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidin-2-one
• CAS: 74958-34-2
• 化学式: C₁₀H₁₅N₃O₄
• 分子量: 241.24
• InChiKey: UAZJPMMKWBPACD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• CARBOCYCLIC COMPOUNDS AND METHODS FOR TREATING EMERGING DISEASE, INCLUDING INFLUENZA AND VENEZUELA EQUINE ENCEPHALITIS VIRUS
  申请人：Chu David

  公开号：US20100144664A1

  公开（公告）日：2010-06-10

  The present invention relates to the use of carbodine and 5-F carbodine and analogs thereof for use in the treatment or prophylaxis of influenza, in particular the H5N1 strain of Avian Influenza A virus or “bird flu” strain of influenza as well as the treatment or prophylaxis of Venezuela equine encephalitis virus or VEE.

  本发明涉及使用卡伯丁和5-F卡伯丁及其类似物用于治疗或预防流感，特别是禽流感A病毒的H5N1亚型或“禽流感”亚型以及治疗或预防委内瑞拉马蹄热病毒或VEE。
• Compositions and methods for reducing neointima formation
  申请人：University of Georgia Research Foundation, Inc.

  公开号：US10328182B2

  公开（公告）日：2019-06-25

  Compositions, devices, grafts and methods for reducing or preventing anti-neointima following cardiovascular injuries and interventions are disclosed. The compositions, devices, and grafts typically include an effective amount of a CTP synthase 1 inhibitor to reduce proliferation of vascular smooth muscle cells, without substantial reducing the proliferation of endothelial cells. Methods of reducing neointima formation, accelerating re-endothelialization, and reducing restenosis in a subject using the compositions, devices, and grafts are also disclosed.

  本研究公开了用于减少或预防心血管损伤和干预后的抗新生血管的组合物、装置、移植物和方法。这些组合物、装置和移植物通常包括有效量的 CTP 合酶 1 抑制剂，以减少血管平滑肌细胞的增殖，而不会大量减少内皮细胞的增殖。此外，还公开了使用这些组合物、装置和移植物减少新内膜形成、加速再内皮化和减少受试者再狭窄的方法。
• COMPOSITIONS AND METHODS FOR REDUCING NEOINTIMA FORMATION
  申请人：University of Georgia Research Foundation, Inc.

  公开号：US20190307929A1

  公开（公告）日：2019-10-10

  Compositions, devices, grafts and methods for reducing or preventing anti-neointima following cardiovascular injuries and interventions are disclosed. The compositions, devices, and grafts typically include an effective amount of a CTP synthase 1 inhibitor to reduce proliferation of vascular smooth muscle cells, without substantial reducing the proliferation of endothelial cells. Methods of reducing neointima formation, accelerating re-endothelialization, and reducing restenosis in a subject using the compositions, devices, and grafts are also disclosed.
• Nucleic acid nanocarrier drug, preparation method, pharmaceutical composition and use thereof
  申请人：BAI YAO ZHI DA (BEIJING) NANOBIO TECHNOLOGY CO., LTD.

  公开号：US20220047617A1

  公开（公告）日：2022-02-17

  Provided are a nucleic acid nanocarrier drug, a preparation method thereof, a pharmaceutical composition and an application thereof. The nucleic acid nanocarrier drug includes a nucleic acid nanoparticle carrier and a drug; and the nucleic acid nanoparticle includes a nucleic acid domain, the nucleic acid domain includes a sequence a, a sequence b and a sequence c, the sequence a includes a sequence a1 or a sequence obtained by insertion, deletion or substitution of at least one base in the sequence a1, the sequence b includes a sequence b1 or a sequence obtained by insertion, deletion or substitution of at least one base in the sequence b1, and the sequence c includes a sequence c1 or a sequence obtained by insertion, deletion or substitution of at least one base in the sequence c1.
• US4232154A
  申请人：——

  公开号：US4232154A

  公开（公告）日：1980-11-04