(E)-ethyl 4-((ethoxycarbonothioyl)thio)-5-(4-methoxyphenyl)pent-2-enoate | 1357589-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (E)-ethyl 4-((ethoxycarbonothioyl)thio)-5-(4-methoxyphenyl)pent-2-enoate
• 英文别名: ethyl (E)-4-ethoxycarbothioylsulfanyl-5-(4-methoxyphenyl)pent-2-enoate
• CAS: 1357589-60-6
• 化学式: C₁₇H₂₂O₄S₂
• 分子量: 354.491
• InChiKey: ODSRJEFBAFSWSN-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  ethyl 2-((ethoxycarbonothioyl)thio)-2-(methylthio)acetate 在 过氧化双月桂酰 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 乙酸乙酯 、 甲苯 为溶剂， 生成 (E)-ethyl 4-((ethoxycarbonothioyl)thio)-5-(4-methoxyphenyl)pent-2-enoate
  参考文献：
  名称：

  A Convenient Conversion of Terminal Alkenes into Homologous Unsaturated and Doubly Unsaturated Esters

  摘要：

  Unsaturated and doubly unsaturated esters have been synthesized in two steps by the application of a radical xanthate transfer process of a simple methylsulfoxide starting material to a range of terminal alkenes. syn-Elimination of the sulfoxide gives alpha,beta-unsaturated esters, which coupled with a xanthate elimination yields alpha,beta,gamma,delta-unsaturated esters.

  DOI：

  10.1021/ol203387r

文献信息

• A Convenient Conversion of Terminal Alkenes into Homologous Unsaturated and Doubly Unsaturated Esters
  作者：Bill Hawkins、Victoria L. Paddock、Nina Tölle、Samir Z. Zard

  DOI：10.1021/ol203387r

  日期：2012.2.17

  Unsaturated and doubly unsaturated esters have been synthesized in two steps by the application of a radical xanthate transfer process of a simple methylsulfoxide starting material to a range of terminal alkenes. syn-Elimination of the sulfoxide gives alpha,beta-unsaturated esters, which coupled with a xanthate elimination yields alpha,beta,gamma,delta-unsaturated esters.