4,4,5,5,6,6,7,7,8,8,9,9-Dodecafluoro-undecanoic acid (2-dimethylamino-ethyl)-ethyl-amide | 501330-07-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4,4,5,5,6,6,7,7,8,8,9,9-Dodecafluoro-undecanoic acid (2-dimethylamino-ethyl)-ethyl-amide
• 英文别名: N-[2-(dimethylamino)ethyl]-N-ethyl-4,4,5,5,6,6,7,7,8,8,9,9-dodecafluoroundecanamide
• CAS: 501330-07-0
• 化学式: C₁₇H₂₄F₁₂N₂O
• 分子量: 500.371
• InChiKey: CFIIXHSZECYXRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  32
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  4,4,5,5,6,6,7,7,8,8,9,9-Dodecafluoro-undecanoic acid (2-dimethylamino-ethyl)-ethyl-amide 在 双氧水 作用下， 以 甲醇 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Synthesis and preliminary biochemical assessment of ethyl-terminated perfluoroalkylamine oxide surfactants

  摘要：

  The synthesis and usefulness in membrane biochemistry of a new class of surfactants have been investigated. 1-Ethyl-2-dimethylamine oxide polar heads were grafted onto a hydrocarbon, a fluorocarbon or an ethyl-capped fluorocarbon hydrophobic tail. The ability of the resulting surfactants to extract and/or to stabilize in aqueous solution a test membrane protein, cytochrome b(6)f, was evaluated. While it is not a detergent, the hemifluorinated derivative efficiently kept purified cytochrome b(6)f soluble, native and functional. The data suggest that alkyl-capped fluorocarbon surfactants provide an interesting alternative to classical detergents for handling membrane proteins in aqueous solutions under non-dissociating conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00242-1
• 作为产物：
  描述：

  4,4,5,5,6,6,7,7,8,8,9,9-Dodecafluoro-undecanoic acid 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 4,4,5,5,6,6,7,7,8,8,9,9-Dodecafluoro-undecanoic acid (2-dimethylamino-ethyl)-ethyl-amide
  参考文献：
  名称：

  Synthesis and preliminary biochemical assessment of ethyl-terminated perfluoroalkylamine oxide surfactants

  摘要：

  The synthesis and usefulness in membrane biochemistry of a new class of surfactants have been investigated. 1-Ethyl-2-dimethylamine oxide polar heads were grafted onto a hydrocarbon, a fluorocarbon or an ethyl-capped fluorocarbon hydrophobic tail. The ability of the resulting surfactants to extract and/or to stabilize in aqueous solution a test membrane protein, cytochrome b(6)f, was evaluated. While it is not a detergent, the hemifluorinated derivative efficiently kept purified cytochrome b(6)f soluble, native and functional. The data suggest that alkyl-capped fluorocarbon surfactants provide an interesting alternative to classical detergents for handling membrane proteins in aqueous solutions under non-dissociating conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00242-1

文献信息

• Synthesis and preliminary biochemical assessment of ethyl-terminated perfluoroalkylamine oxide surfactants
  作者：Yann Chaudier、Francesca Zito、Philippe Barthélémy、David Stroebel、Bruno Améduri、Jean-Luc Popot、Bernard Pucci

  DOI：10.1016/s0960-894x(02)00242-1

  日期：2002.6

  The synthesis and usefulness in membrane biochemistry of a new class of surfactants have been investigated. 1-Ethyl-2-dimethylamine oxide polar heads were grafted onto a hydrocarbon, a fluorocarbon or an ethyl-capped fluorocarbon hydrophobic tail. The ability of the resulting surfactants to extract and/or to stabilize in aqueous solution a test membrane protein, cytochrome b(6)f, was evaluated. While it is not a detergent, the hemifluorinated derivative efficiently kept purified cytochrome b(6)f soluble, native and functional. The data suggest that alkyl-capped fluorocarbon surfactants provide an interesting alternative to classical detergents for handling membrane proteins in aqueous solutions under non-dissociating conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.