2,4-Dimethoxy-6-hydroxypyrimidin | 52280-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-Dimethoxy-6-hydroxypyrimidin
• 英文别名: 2-methoxy-4-methoxy-6-hydroxypyrimidine；2,4-dimethoxy-1H-pyrimidin-6-one
• CAS: 52280-97-4
• 化学式: C₆H₈N₂O₃
• 分子量: 156.141
• InChiKey: QLWSZPOUFUHKDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-Dimethoxy-6-hydroxypyrimidin 、 重氮甲烷 生成 2,4,6-三甲氧基嘧啶
  参考文献：
  名称：

  KRASNOV, K. A.;SLESAREV, V. I.;ZAXAROV, A. P.;GRIGOREVA, EH. G., XIMIYA GETEROTSIKL. SOED.,(1987) N 11, 1523-1526

  摘要：

  DOI：
• 作为产物：
  描述：

  6-Fluor-2,4-dimethoxy-pyrimidin 在 氢氧化钾 作用下， 以 水 、 丙酮 为溶剂， 反应 2.0h， 以60%的产率得到2,4-Dimethoxy-6-hydroxypyrimidin
  参考文献：
  名称：

  Krasnov, K. A.; Slesareva, V. I.; Studentsov, E. P., Journal of Organic Chemistry USSR (English Translation), 1987, vol. 23, # 9, p. 1765 - 1769

  摘要：

  DOI：

文献信息

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  公开号：US20180334523A1

  公开（公告）日：2018-11-22

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  申请人：Sandoz Ltd., (Sandoz AG)

  公开号：US03931180A1

  公开（公告）日：1976-01-06

  The present invention concerns novel 4-hydroxypyrimidine derivatives of the formula: ##SPC1## Wherein R.sub.1 is a substituent, e.g., alkyl, R.sub.2 is hydrogen or a substituent, e.g., alkyl R.sub.3 is amino unsubstituted or substituted by alkyl, a nitrogen heterocycle, alkoxy or alkylthio, which are used as intermediates in the production of useful insecticides.

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  公开号：US04045561A1

  公开（公告）日：1977-08-30

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  本发明涉及新颖的嘧啶磷酸酯和硫代磷酸酯。其中R.sub.1、R.sub.2和R.sub.3是取代基，例如烷基，R.sub.4是氨基或杂环功能基，Z和Y是桥接功能基，例如氧。这些化合物是有用的杀虫剂。
• Process for preparing fluorine-containing norbornene derivative
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20040214103A1

  公开（公告）日：2004-10-28

  There are provided a novel norbornene derivative which is a material for a chemically amplifying type photoresist for F 2 laser, possesses excellent transparency and improved dry etching resistivity and has a fluorine-containing ketone unit or fluorine-containing tertiary alcohol unit directly bonded to the norbornene backbone; a fluorine-containing polymer obtained by using the norbornene derivative as a copolymerizable monomer; and a chemically amplifying type photoresist composition comprising the fluorine-containing polymer, a photoacid generator and a solvent.

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• Benzhydryl derivatives
  申请人：Take Kazuhiko

  公开号：US20050171350A1

  公开（公告）日：2005-08-04

  A compound of the formula (I): in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.

  一种化合物的公式(I)：其中R1、R2、R3、R4、R5、R6、R7、R8和R9分别如描述中所定义，或其盐。本发明的目标化合物具有Tachykinin拮抗作用等药理活性，可用于制造用于治疗或预防Tachykinin介导疾病的药物。