3-t-Butyloxindol | 63023-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-t-Butyloxindol
• 英文别名: 3-tert-Butyloxindol；3-(tert-butyl)indolin-2-one；3-tert-butyl-1,3-dihydro-indol-2-one；3-tert-butyl-2,3-dihydro-1H-indol-2-one；3-tert-butyl-1,3-dihydroindol-2-one
• CAS: 63023-68-7
• 化学式: C₁₂H₁₅NO
• mdl: MFCD19369910
• 分子量: 189.257
• InChiKey: ZWUOJQIVHKBXQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (E)-2-(2-(benzylideneamino)phenyl)-N,3,3-trimethyl-N-(methylsulfonyl)butanamide 在 水 作用下， 以96%的产率得到3-t-Butyloxindol
  参考文献：
  名称：

  Gold-Catalyzed 1,2-Difunctionalizations of Aminoalkynes Using Only N- and O-Containing Oxidants

  摘要：

  We report two viable routes for the 1,2difunctionalization of aminoalkynes using only oxidants. In the presence of a gold catalyst, nitrones enable the oxoamination of aminoalkynes 1 to form 2-aminoamides 2. With a suitable gold catalyst, nitrosobenzenes implement an alkyne/nitroso metathesis of the same substrates to give 2-oxoiminylamides 3. These two novel oxidations also provide 1,2-aminoalcohols with opposite regioselectivity via NaBH4 reduction in situ.

  DOI：

  10.1021/ja208150d

文献信息

• BENZIMIDAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
  申请人：Aktoudianakis Evangelos

  公开号：US20160075695A1

  公开（公告）日：2016-03-17

  This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R 1 , R 1b , R 2a , R 2b , R 3 , R 4a , R 4b , and R 5 are described herein.

  该应用涉及化合物，这些化合物可以作为溴域含有蛋白质的抑制剂，或者以其他方式调节其活性，包括溴域含有蛋白质4（BRD4），以及包含这些化合物的组成物和配方，以及使用和制造这些化合物的方法。 化合物包括公式（I）中描述的R1，R1b，R2a，R2b，R3，R4a，R4b和R5的化合物。
• Benzimidazole derivatives as bromodomain inhibitors
  申请人：Gilead Sciences, Inc.

  公开号：US10017501B2

  公开（公告）日：2018-07-10

  This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

  本申请涉及可作为含溴结构域蛋白（包括含溴结构域蛋白 4 (BRD4)）的抑制剂或以其它方式调节其活性的化合物，还涉及含有此类化合物的组合物和制剂，以及使用和制造此类化合物的方法。化合物包括式（I）化合物 其中 R1a、R1b、R2a、R2b、R3、R4a、R4b 和 R5 如本文所述。
• K-Ras modulators
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US11358940B2

  公开（公告）日：2022-06-14

  Provided herein are the K-Ras inhibitors of the formulae: Also provided are compositions comprising thereof for treating cancer.

  本文提供了式中的 K-Ras 抑制剂： 还提供了包含其用于治疗癌症的组合物。
• Sufonamides and Uses Thereof
  申请人：Saunders Jeffrey O.

  公开号：US20080261970A1

  公开（公告）日：2008-10-23

  Compounds of formula (I), including methods of making and methods of using are described in formula (I).
• K-RAS MODULATORS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20200247762A1

  公开（公告）日：2020-08-06

  Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer.