S-tert-Butyl-L-cysteine Benzyl Ester | 76499-05-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-tert-Butyl-L-cysteine Benzyl Ester
• 英文别名: benzyl (2R)-2-amino-3-tert-butylsulfanylpropanoate
• CAS: 76499-05-3
• 化学式: C₁₄H₂₁NO₂S
• 分子量: 267.392
• InChiKey: YGGRDVINOCRLOI-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  S-tert-Butyl-L-cysteine Benzyl Ester 在 20percent Pd(OH)2/C 氢气 、 三乙胺 作用下， 以 二氯甲烷 、 乙酸乙酯 、 叔丁醇 为溶剂， 生成 (R)-3-tert-Butylsulfanyl-2-[3-((R)-2-tert-butylsulfanyl-1-carboxy-ethyl)-ureido]-propionic acid
  参考文献：
  名称：

  Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Carboxypeptidase II (NAALADase)

  摘要：

  DOI：

  10.1021/jm000406m

文献信息

• S-t-BUTYL PROTECTED CYSTEINE DI-PEPTIDE ANALOGS AND RELATED COMPOUNDS
  申请人：Johnson, II Edward M.

  公开号：US20120122792A1

  公开（公告）日：2012-05-17

  S-t-butyl protected cysteine di-peptide analogs and related compounds and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of Central Nervous System (CNS).

  S-叔丁基保护的半胱氨酸二肽类似物和相关化合物以及使用这些化合物治疗疾病和/或症状的方法，包括但不限于中枢神经系统（CNS）疾病和/或症状。
• LIGANDS FOR METABOTROPIC GLUTAMATE RECEPTORS AND INHIBITORS OF NAALADASE
  申请人：Kozikowski Alan P.

  公开号：US20080176821A1

  公开（公告）日：2008-07-24

  The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
• US7381745B2
  申请人：——

  公开号：US7381745B2

  公开（公告）日：2008-06-03
• US8624052B2
  申请人：——

  公开号：US8624052B2

  公开（公告）日：2014-01-07
• Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Carboxypeptidase II (NAALADase)
  作者：Alan P. Kozikowski、Fajun Nan、Paola Conti、Jiazhong Zhang、Epolia Ramadan、Tomasz Bzdega、Barbara Wroblewska、Joseph H. Neale、Sergey Pshenichkin、Jarda T. Wroblewski

  DOI：10.1021/jm000406m

  日期：2001.2.1